News Column

Findings on Nanoparticles Detailed by Investigators at University of Hyogo

June 20, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Nanoparticles are discussed in a new report. According to news originating from Himeji, Japan, by NewsRx correspondents, research stated, "DNA molecules possessing multiple ferrocene (Fc) molecules as a redox active probe were prepared by the primer extension (PEX) reaction using a 2'-deoxyuridine-5'-triphosphate derivative in which Fc was connected to the C5-position of the uridine by a diethylene glycol linker."

Our news journalists obtained a quote from the research from the University of Hyogo, "Gold nanoparticles (AuNP) covered with DNA possessing the Fc molecules were prepared by the PEX reaction on the surface. The AuNP-FcDNA conjugates exhibit a detectable electrochemical signal due to the Fc molecules."

According to the news editors, the research concluded: "Possible application of the PEX reaction on AuNP is demonstrated for the detection of a single nucleotide mutation in the target DNA."

For more information on this research see: Preparation of ferrocene-functionalized gold nanoparticles by primer extension reaction on the particle surface. Bioorganic & Medicinal Chemistry Letters, 2014;24(12):2661-2663. Bioorganic & Medicinal Chemistry Letters can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Bioorganic & Medicinal Chemistry Letters - www.elsevier.com/wps/product/cws_home/972)

The news correspondents report that additional information may be obtained from T. Takada, University of Hyogo, Grad Sch Engn, Dept. of Mat Sci & Chem, Himeji, Hyogo 6712280, Japan. Additional authors for this research include T. Tochi, M. Nakamura and K. Yamana (see also Nanoparticles).

Keywords for this news article include: Asia, Japan, Himeji, Nanotechnology, Gold Nanoparticles, Emerging Technologies

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Source: Health & Medicine Week