News Column

Findings on DNA Research Detailed by Researchers at University Putra Malaysia

June 18, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on DNA Research have been presented. According to news reporting from Selangor, Malaysia, by NewsRx journalists, research stated, "Although nanoparticle-enhanced biosensors have been extensively researched, few studies have systematically characterized the roles of nanoparticles in enhancing biosensor functionality. This paper describes a successful new method in which DNA binds directly to iron oxide nanoparticles for use in an optical biosensor."

The news correspondents obtained a quote from the research from University Putra Malaysia, "A wide variety of nanoparticles with different properties have found broad application in biosensors because their small physical size presents unique chemical, physical, and electronic properties that are different from those of bulk materials. Of all nanoparticles, magnetic nanoparticles are proving to be a versatile tool, an excellent case in point being in DNA bioassays, where magnetic nanoparticles are often used for optimization of the hybridization and separation of target DNA. A critical step in the successful construction of a DNA biosensor is the efficient attachment of biomolecules to the surface of magnetic nanoparticles. To date, most methods of synthesizing these nanoparticles have led to the formation of hydrophobic particles that require additional surface modifications. As a result, the surface to volume ratio decreases and nonspecific bindings may occur so that the sensitivity and efficiency of the device deteriorates. A new method of large-scale synthesis of iron oxide (Fe3O4) nanoparticles which results in the magnetite particles being in aqueous phase, was employed in this study. Small modifications were applied to design an optical DNA nanosensor based on sandwich hybridization. Characterization of the synthesized particles was carried out using a variety of techniques and CdSe/ZnS core-shell quantum dots were used as the reporter markers in a spectrofluorophotometer."

According to the news reporters, the research concluded: "We showed conclusively that DNA binds to the surface of ironoxide nanoparticles without further surface modifications and that these magnetic nanoparticles can be efficiently utilized as biomolecule carriers in biosensing devices."

For more information on this research see: A novel DNA nanosensor based on CdSe/ZnS quantum dots and synthesized Fe3O4 magnetic nanoparticles. Molecules, 2014;19(4):4355-68. (Springer -; Molecules -

Our news journalists report that additional information may be obtained by contacting R. Hushiarian, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Additional authors for this research include N.A. Yusof, A.H. Abdullah, S.A. Ahmad and S.W Dutse (see also DNA Research).

Keywords for this news article include: Asia, Selangor, Malaysia, Biosensing, DNA Research, Nanoparticle, Quantum Dots, Bioengineering, Quantum Physics, Bionanotechnology, Nanobiotechnology, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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