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Findings from University of Ferrara Broaden Understanding of Scleroproteins

June 20, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Proteins have been published. According to news reporting originating in Ferrara, Italy, by NewsRx journalists, research stated, "Gelatin/Collagen-based matrix and reservoir nanoparticles require crosslinkers to stabilize the formed nanosuspensions, considering that physical instability is the main challenge of nanoparticulate systems. The use of crosslinkers improves the physical integrity of nanoformulations under the-host environment."

The news reporters obtained a quote from the research from the University of Ferrara, "Aldehyde-based fixatives, such as formaldehyde and glutaraldehyde, have been widely applied to the crosslinking process of polymeric nanoparticles. However, their potential toxicity towards human beings has been demonstrated in many previous studies. In order to tackle this problem, is-glucose was used during nanoparticle formation to stabilize the gelatin/collagen-based matrix wall and reservoir wall for the deliveries of Calendula officinalis powder and oil, respectively. In addition, therapeutic selectivity between malignant and normal cells could be observed. The C officinalis powder loaded nanoparticles significantly strengthened the anti-cancer effect towards human breast adenocarcinoma MCF7 cells and human hepatoma SKHep1 cells when compared with the free powder. On the contrary, the nanoparticles did not show significant cytotoxicity towards normal esophageal epithelial NE3 cells and human skin keratinocyte HaCaT cells."

According to the news reporters, the research concluded: "On the basis of these evidences, c-glucose modified gelatin/collagen matrix nanoparticles containing C. officinalis powder might be proposed as a safer alternative vehicle for anticancer treatments."

For more information on this research see: D-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery. Colloids and Surfaces B-Biointerfaces, 2014;117():277-283. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Proteins).

Our news correspondents report that additional information may be obtained by contacting P.L. Lam, University of Ferrara, Dept. of Life Sci & Biotechnol, Center Biotechnol, I-44100 Ferrara, Italy. Additional authors for this research include S.H.L. Kok, Z.X. Bian, K.H. Lam, J.C.O. Tang, K.K.H. Lee, R. Gambari and C.H. Chui.

Keywords for this news article include: Italy, Europe, Ferrara, Gelatin, Collagen, Nanoparticle, Therapeutics, Nanotechnology, Scleroproteins, Emerging Technologies, Extracellular Matrix Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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