News Column

Findings from University of Copenhagen in the Area of Glioblastomas Described

June 16, 2014

By a News Reporter-Staff News Editor at Clinical Oncology Week -- Investigators publish new report on Oncology. According to news originating from Frederiksberg, Denmark, by NewsRx correspondents, research stated, "The carbon-based nanomaterial family consists of nanoparticles containing allotropes of carbon, which may have a number of interactions with biological systems. The objective of this study was to evaluate the toxicity of nanoparticles comprised of pristine graphene, reduced graphene oxide, graphene oxide, graphite, and ultradispersed detonation diamond in a U87 cell line."

Our news journalists obtained a quote from the research from the University of Copenhagen, "The scope of the work consisted of structural analysis of the nanoparticles using transmission electron microscopy, evaluation of cell morphology, and assessment of cell viability by Trypan blue assay and level of DNA fragmentation of U87 cells after 24 hours of incubation with 50 mu g/mL carbon nanoparticles. DNA fragmentation was studied using single-cell gel electrophoresis. Incubation with nanoparticles containing the allotropes of carbon did not alter the morphology of the U87 cancer cells. However, incubation with pristine graphene and reduced graphene oxide led to a significant decrease in cell viability, whereas incubation with graphene oxide, graphite, and ultradispersed detonation diamond led to a smaller decrease in cell viability."

According to the news editors, the research concluded: "The results of a comet assay demonstrated that pristine graphene, reduced graphene oxide, graphite, and ultradispersed detonation diamond caused DNA damage and were therefore genotoxic in U87 cells, whereas graphene oxide was not."

For more information on this research see: Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells. International Journal of Nanomedicine, 2014;9():2409-2417. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).

The news correspondents report that additional information may be obtained from M. Hinzmann, University of Copenhagen, Dept. of Vet Clin & Anim Sci, DK-1870 Frederiksberg, Denmark. Additional authors for this research include S. Jaworski, M. Kutwin, J. Jagiello, R. Kozinski, M. Wierzbicki, M. Grodzik, L. Lipinska, E. Sawosz and A. Chwalibog.

Keywords for this news article include: Europe, Denmark, Oncology, Glioblastoma, Frederiksberg

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Source: Clinical Oncology Week

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