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Findings from Nanjing University in the Area of Immunoglobulins Described

June 17, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Immunology have been published. According to news reporting originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "Magnetic Fe70Co30 nanoparticles with a cubic shape and a mean size of 15 +/- 1.5 nm were fabricated using a magnetron-sputtering-based gas phase condensation deposition method. The particles had a high saturation magnetization of 220 emu/g, which is much higher than that of commercially available iron oxide nanoparticles."

Our news editors obtained a quote from the research from Nanjing University, "The FeCo nanoparticles were modified by 3-aminopropyltriethoxy silane and subsequently activated by glutaraldehyde, leading to successful attachment of aldehyde groups onto nanoparticle surfaces. Three proteins, namely streptavidin, PAPP-A antibody and Nectin-4 antibody, were immobilized on glutaraldehyde activated FeCo nanoparticles, and their loading levels were quantitatively evaluated. Our results show that loading capabilities are 95 mu g of streptavidin, 128 p.,g of PAPP-A, and 125 mu g of Nectin-4 antibody per milligram of FeCo nanoparticles, and that the three immobilized proteins retain their binding bioactivity."

According to the news editors, the research concluded: "The protein-FeCo conjugates may find valuable applications involving magnetic separation and purification of proteins and cells, and the magnetic detection of biomolecules."

For more information on this research see: Surface modification and bioconjugation of FeCo magnetic nanoparticles with proteins. Colloids and Surfaces B-Biointerfaces, 2014;117():449-456. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Immunology).

The news editors report that additional information may be obtained by contacting W. Wang, Nanjing University, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210046, Jiangsu, People's Republic of China. Additional authors for this research include Y. Jing, S.H. He, J.P. Wang and J.P. Zhai.

Keywords for this news article include: Asia, Antibodies, Jiangsu, Peptides, Immunology, Amino Acids, Nanoparticle, Blood Proteins, Nanotechnology, Immunoglobulins, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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