News Column

Findings from Masaryk University Provide New Insights into Metalloproteins

June 17, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteins have been published. According to news reporting originating in Brno, Czech Republic, by NewsRx journalists, research stated, "Nanoparticles have gained increasing interest in medical and in vivo applications. Metallothionein (MT) is well known as a maintainer of metal ions balance in intracellular space."

The news reporters obtained a quote from the research from Masaryk University, "This is due to high affinity of this protein to any reactive species including metals and reactive oxygen species. The purpose of this study was to determine the metallothionein-quantum dots interactions that were investigated by spectral and electrochemical techniques. CuS, CdS, PbS, and CdTe quantum dots (QDs) were analysed. The highest intensity was shown for CdTe, than for CdS measured by fluorescence. These results were supported by statistical analysis and considered as significant. Further, these interactions were analysed using gel electrophoresis, where MT aggregates forming after interactions with QDs were detected. Using differential pulse voltammetry Brdicka reaction, QDs and MT were studied."

According to the news reporters, the research concluded: "This method allowed us to confirm spectral results and, moreover, to observe the changes in MT structure causing new voltammetric peaks called X and Y, which enhanced with the prolonged time of interaction up to 6 h."

For more information on this research see: Study of metallothionein-quantum dots interactions. Colloids and Surfaces B-Biointerfaces, 2014;117():534-537. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Proteins).

Our news correspondents report that additional information may be obtained by contacting K. Tmejova, Masaryk University, Fac Sci, Dept. of Chem, CZ-62500 Brno, Czech Republic. Additional authors for this research include D. Hynek, P. Kopel, S. Krizkova, I. Blazkova, L. Trnkova, V. Adam and R. Kizek.

Keywords for this news article include: Brno, Europe, Quantum Dots, Czech Republic, Metalloproteins, Metallothionein, Quantum Physics

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Source: Life Science Weekly