By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Myeloid Cells. According to news originating from Sendai, Japan, by NewsRx correspondents, research stated, "Amorphous silica particles, such as nanoparticles (
Our news journalists obtained a quote from the research from Tohoku University, "In this study, we addressed the relationship between the size of amorphous silica (particle dose, diameter, number, and surface area) and the inflammatory activity (macrophage phagocytosis, inflammasome activation, IL-1? secretion, cell death and lung inflammation). Irrespective of diameter size, silica particles were efficiently internalized by mouse bone marrow-derived macrophages via an actin cytoskeleton-dependent pathway, and induced caspase-1, but not caspase-11, activation. Of note, 30 nm-1000 nm diameter silica particles induced lysosomal destabilization, cell death, and IL-1? secretion at markedly higher levels than did 3000 nm-10000 nm silica particles. Consistent with in vitro results, intra-tracheal administration of 30 nm silica particles into mice caused more severe lung inflammation than that of 3000 nm silica particles, as assessed by measurement of pro-inflammatory cytokines and neutrophil infiltration in bronchoalveolar lavage fluid of mice, and by the micro-computed tomography analysis."
According to the news editors, the research concluded: "Taken together, these results suggest that silica particle size impacts immune responses, with submicron amorphous silica particles inducing higher inflammatory responses than silica particles over 1000 nm in size, which is ascribed not only to their ability to induce caspase-1 activation but also to their cytotoxicity."
For more information on this research see: Effect of silica particle size on macrophage inflammatory responses. Plos One, 2014;9(3):e92634. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
The news correspondents report that additional information may be obtained from T. Kusaka, Dept. of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. Additional authors for this research include M. Nakayama, K. Nakamura, M. Ishimiya, E. Furusawa and K. Ogasawara (see also Myeloid Cells).
Keywords for this news article include: Asia, Japan, Sendai, Caspases, Immunology, Macrophages, Myeloid Cells, Peptide Hydrolases, Enzymes and Coenzymes, Connective Tissue Cells, Cysteine Endopeptidases, Mononuclear Phagocyte System.
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