News Column

Data from General Hospital Advance Knowledge in Cancer Gene Therapy

June 16, 2014



By a News Reporter-Staff News Editor at Obesity & Diabetes Week -- Fresh data on Biotechnology are presented in a new report. According to news reporting from Liaoning, People's Republic of China, by NewsRx journalists, research stated, "Malignant gliomas are the most common of primary brain tumors and have been proven incurable with conventional treatments. Evidence have shown that a recombinant adenoviral vector expressing human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes (BB-102) may have antitumor effects in vitro."

The news correspondents obtained a quote from the research from General Hospital, "In this study, we investigated the effects of BB-102-based vaccine on glioma in vivo. An animal model using nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice with human immune system was established. The mice were vaccinated with inactivated U251 glioma cells transduced with BB-102 or adenoviral vector expressing green fluorescence protein (Ad-GFP) as a control and followed by the challenge of live U251 glioma cells. Tumor growth and antitumor responses were measured. Data showed that mice vaccinated with BB-102 had significantly reduced local tumor growth compared to mice with Ad-GFP vaccination or the control group. Histopathological analysis displayed low tumor cell density and significant infiltration of human peripheral blood lymphocytes (HuPBLs) in the tumor tissues of mice transduced with BB-102. Immunohistochemical analysis showed that mutant p53 was not expressed in tumor tissues of mice with BB-102 vaccination, and the expression level of Ki67 was significantly lower in the tumor tissues of the BB-102 group than those in the Ad-GFP group or the control group. Further study demonstrated that mice with BB-102 vaccination had significantly increased total T cell numbers, total T cell proportion, CD4+ T cell proportion, and CD8+ T cell proportion in spleens, as well as higher value of IgG, IgA, and IgE in sera."

According to the news reporters, the research concluded: "These data suggest that the recombinant adenoviral vector expressing human wild-type p53, GM-CSF, and B7-1 genes could suppress glioma in NOD/SCID mice model and might be considered as a novel strategy for glioma therapy."

For more information on this research see: Recombinant adenoviral vector expressing human wild-type p53, GM-CSF, and B7-1 genes suppresses the growth of glioma in vivo. Tumor Biology, 2014;35(5):4411-4417. Tumor Biology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Tumor Biology - www.springerlink.com/content/1010-4283/)

Our news journalists report that additional information may be obtained by contacting S.H. Feng, Chinese PLA, Shenyang Military Area Command, General Hospital, Dept. of Neurosurg, Shenyang 110016, Liaoning, People's Republic of China. Additional authors for this research include S. Han, D.S. Pan, M.P. Liu, X.L. Feng, T. Dong, W. Li and X.Z. Wei (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Glioma, Liaoning, Genetics, Oncology, p53 Gene, Vaccination, Immunization, People's Republic of China, Clinical Trials and Studies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Obesity & Diabetes Week


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