By a News Reporter-Staff News Editor at Physics Week -- Fresh data on Nanoparticles are presented in a new report. According to news reporting from Nanjing, People's Republic of China, by VerticalNews journalists, research stated, "Nanoparticles (NPs) show great promises in biomedical applications as the respiratory drug carrier system. Once reaching the alveolar region, NPs first interact with the pulmonary surfactant (PS) film, which serves as the first biological barrier and plays an important role in maintaining the normal respiratory mechanics."
The news correspondents obtained a quote from the research from Southeast University, "Therefore, understanding the interactions between NPs and PS can help promote the NP-based respiratory drug carrier systems. Using coarse-grained molecular dynamics simulations, we studied the effect of rigid spherical NPs with different hydrophobicity and sizes on a dipalmitoylphosphatidylcholine (DPPC) monolayer at the air-water interface. Four different NPs were considered, including hydrophilic and hydrophobic NPs, each with two diameters of 3 nm and 5 nm (the sizes are comparable to that of generation 3 and 5 PAMAM dendrimers, which have been widely used for nanoscale drug carrier systems). Our simulations showed that hydrophilic NPs can readily penetrate into the aqueous phase with little or no disturbance on the DPPC monolayer. However, hydrophobic NPs tend to induce large structural disruptions, thus inhibiting the normal phase transition of the DPPC monolayer upon film compression. Our simulations also showed that this inhibitory effect of hydrophobic NPs can be mitigated through PEGylation."
According to the news reporters, the research concluded: "Our results provide useful guidelines for molecular design of NPs as carrier systems for pulmonary drug delivery."
For more information on this research see: Promote potential applications of nanoparticles as respiratory drug carrier: insights from molecular dynamics simulations. Nanoscale, 2014;6(5):2759-67. (Royal Society of Chemistry - www.rsc.org/; Nanoscale - pubs.rsc.org/en/journals/journalissues/nr)
Our news journalists report that additional information may be obtained by contacting X. Lin, State Key Laboratory of Bioelectronics and Jiangsu key Laboratory for Biomaterials and Devices, School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, People's Republic of China. Additional authors for this research include T. Bai, Y.Y. Zuo and N. Gu.
Keywords for this news article include: Asia, Nanjing, Physics, Nanotechnology, Molecular Dynamics, Emerging Technologies, People's Republic of China.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC