News Column

New Findings Reported from Hong Kong University of Science and Technology Describe Advances in Nanoparticles

May 16, 2014

By a News Reporter-Staff News Editor at Science Letter -- New research on Nanoparticles is the subject of a report. According to news reporting from Hong Kong, People's Republic of China, by NewsRx journalists, research stated, "BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) is an emissive chromophore in solutions but suffers from fluorescence quenching when aggregated due to its flat molecular conformation and small Stokes shift. To create aggregate-state emissive BODIPY luminogens, tetraphenylethene (TPE), which is a popular luminogen with intriguing aggregation-induced emission (AIE) characteristic, is introduced as periphery to a methylated BODIPY core."

The news correspondents obtained a quote from the research from the Hong Kong University of Science and Technology, "Three TPE-BODIPY adducts are synthesized and characterized, and their photophysical properties and electronic structures are investigated. The incorporation of AIE-active TPE units alleviates aggregation-caused quenching of BODIPY core, furnishing emissive nanoparticles based on TPE-BODIPY adducts. Significantly, the two-photon absorption (TPA) and two-photon excited fluorescence (TPEF) properties are improved as more TPE units are attached. The luminogens with 3TPE units (3TPE-BODIPY) shows the strongest TPA and TPEF in the wavelength range of 750-830 nm, with cross-section values of 264 and 116 GM at 810 nm, respectively. Red emissive nanoparticles with a Stokes shift of 60 nm and a fluorescence quantum yield of 16% are attained by encapsulating 3TPE-BODIPY with 1,2-sistearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]."

According to the news reporters, the research concluded: "The nanoparticles are biocompatible and function well in TPEF cellular imaging and mouse brain blood vascular visualization."

For more information on this research see: Red Emissive Biocompatible Nanoparticles from Tetraphenylethene-Decorated BODIPY Luminogens for Two-Photon Excited Fluorescence Cellular Imaging and Mouse Brain Blood Vascular Visualization. Particle & Particle Systems Characterization, 2014;31(4):481-491. Particle & Particle Systems Characterization can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Particle & Particle Systems Characterization -

Our news journalists report that additional information may be obtained by contacting Z.J. Zhao, Hong Kong University of Science & Technology, Inst Mol Funct Mat, Kowloon, Hong Kong, People's Republic of China. Additional authors for this research include B. Chen, J.L. Geng, Z.F. Chang, L. Aparicio-Ixta, H. Nie, C.C. Goh, L.G. Ng, A.J. Qin, G. Ramos-Ortiz, B. Liu and B.Z. Tang (see also Nanoparticles).

Keywords for this news article include: Asia, Hong Kong, Nanotechnology, Emerging Technologies, People's Republic of China

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Source: Science Letter

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