By a News Reporter-Staff News Editor at Biotech Week -- New research on Peptides is the subject of a report. According to news originating from Fuzhou, People's Republic of China, by NewsRx correspondents, research stated, "Glutathione (GSH) plays key roles in biological systems and serves many cellular functions. Since biothiols all incorporate thiol, carboxylic and amino groups, discriminative detection of GSH over cysteine (Cys) and homocysteine (Hcy) is still challenging."
Our news journalists obtained a quote from the research from Fuzhou University, "We herein report a dual-mode nanosensor with both colorimetric and fluorometric readout based on carbon quantum dots and gold nanoparticles for discriminative detection of GSH over Cys/Hcy. The proposed sensing system consists of AuNPs and fluorescent carbon quantum dots (CQDs), where CQDs function as fluorometric reporter, and AuNPs serve a dual function as colorimetric reporter and fluorescence quencher. The mechanism of the nanosensor is based on two distance-dependent phenomenons, color change of AuNPs and FRET. Through controlling the surface properties of as-prepared nanoparticles, the addition of CQDs into AuNPs colloid solution might induce the aggregation of AuNPs and CQDs, leading to AuNPs color changing from red to blue and CQDs fluorescence quench. However, the presence of GSH can protect AuNPs from being aggregated and enlarge the inter-particle distance, which subsequently produces color change and fluorescent signal recovery. The nanosensor described in this report reflects on its simplicity and flexibility, where no further surface functionalization is required for the as-prepared nanoparticles, leading to less laborious and more cost-effective synthesis. The proposed dual-mode nanosensor demonstrated highly selectivity toward GSH, and allows the detection of GSH as low as 50 nM."
According to the news editors, the research concluded: "More importantly, the nanosensor could not only function in aqueous solution for GSH detection with high sensitivity but also exhibit sensitive responses toward GSH in complicated biological environments, demonstrating its potential in bioanalysis and biodection, which might be significant in disease diagnosis in the future."
For more information on this research see: A dual-mode nanosensor based on carbon quantum dots and gold nanoparticles for discriminative detection of glutathione in human plasma. Biosensors & Bioelectronics, 2014;56():39-45. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)
The news correspondents report that additional information may be obtained from Y.P. Shi, Fuzhou Univ, Dept. of Chem, Minist Educ & Fujian Prov, Key Lab Anal & Detect Technol Food Safety, Fuzhou 350002, People's Republic of China. Additional authors for this research include Y. Pan, H. Zhang, Z.M. Zhang, M.J. Li, C.Q. Yi and M.S. Yang (see also Peptides).
Keywords for this news article include: Asia, Fuzhou, Glutathione, Quantum Dots, Oligopeptides, Nanotechnology, Quantum Physics, Gold Nanoparticles, Emerging Technologies, People's Republic of China
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