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Researchers' Work from University of Isfahan Focuses on DNA Research

May 14, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on DNA Research have been published. According to news reporting from Isfahan, Iran, by NewsRx journalists, research stated, "Herein we describe improved electron transfer properties and catalytic activity of nickel oxide nanopartides (NiONPs) via the electrochemical deposition on DNA modified glassy carbon electrode (DNA/GCE) surface. NiONPs deposited on the bare and DNA-coated GCE showed different morphologies, electrochemical kinetics and catalytic activities."

The news correspondents obtained a quote from the research from the University of Isfahan, "The atomic force microscopy (AFM) images revealed the formation of triangular NPs on the DNA/GCE that followed the shape produced by the DNA template, while the electrodeposition of NiONPs on the bare GCE surface led to the formation of spherical nanoparticles. Electrochemical impedance spectroscopy (EIS) measurements revealed lower charge-transfer resistance (R-ct) of triangular NiONPs compared to spherical NPs. Furthermore, the electrocatalytic activity of triangular NiONPs compared to spherical NPs toward glucose oxidation in alkaline media was significantly improved. The amperometric oxidation of glucose at NiONP-DNA/GCE, yielded a very high sensitivity of 17.32 mA mM(-1) cm(-2) and an unprecedented detection limit of 17 nM. The enhanced electron transfer properties and electrocatalytic activity of NiONP-DNA/GCE can be attributed to the higher fraction of sharp corners and edges present in the triangular NiONPs compared to the spherical NPs."

According to the news reporters, the research concluded: "The developed sensor was successfully applied to the determination of glucose in serum samples."

For more information on this research see: Shape-dependent electron transfer kinetics and catalytic activity of NiO nanoparticles immobilized onto DNA modified electrode: Fabrication of highly sensitive enzymeless glucose sensor. Biosensors & Bioelectronics, 2014;56():313-319. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biosensors & Bioelectronics -

Our news journalists report that additional information may be obtained by contacting E. Sharifi, Univ Isfahan, Fac Adv Sci & Technol, Dept. of Nanotechnol Engn, Hezar Jarib 8174673441, Isfahan, Iran. Additional authors for this research include A. Salimi, E. Shams, A. Noorbakhsh and M.K. Amini (see also DNA Research).

Keywords for this news article include: Iran, Asia, Isfahan, Chemistry, DNA Research, Nanoparticle, Nanotechnology, Electrochemical, Emerging Technologies

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Source: Biotech Week

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