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Researchers at Yale University School of Medicine Describe Findings in Stem Cells

May 12, 2014



By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on Stem Cell Research is now available. According to news originating from New Haven, Connecticut, by NewsRx correspondents, research stated, "During brain development, neural stem cells (NSCs) receive on-or-off signals important for regulating their amplification and reaching adequate neuron density. However, how a coordinated regulation of intracellular pathways and genetic programs is achieved has remained elusive."

Our news journalists obtained a quote from the research from the Yale University School of Medicine, "Here, we found that the embryonic (e) CSF contains 10 nanoparticles/ml (77 nm diameter), some of which were identified as exosome nanovesicles that contain evolutionarily conserved molecules important for coordinating intracellular pathways. eCSF nanovesicles collected from rodent and human embryos encapsulate protein and microRNA components of the insulin-like growth factor (IGF) signaling pathway. Supplementation of eCSF nanovesicles to a mixed culture containing eNSCs activated the IGF-mammalian target of rapamycin complex 1 (mTORC1) pathway in eNSCs and expanded the pool of proliferative eNSCs."

According to the news editors, the research concluded: "These data show that the eCSF serves as a medium for the distribution of nanovesicles, including exosomes, and the coordinated transfer of evolutionary conserved molecules that regulate eNSC amplification during corticogenesis."

For more information on this research see: Embryonic cerebrospinal fluid nanovesicles carry evolutionarily conserved molecules and promote neural stem cell amplification. Plos One, 2014;9(2):e88810. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

The news correspondents report that additional information may be obtained from D.M. Feliciano, Departments of Neurosurgery and Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States. Additional authors for this research include S. Zhang, C.M. Nasrallah, S.N. Lisgo and A. Bordey (see also Stem Cell Research).

Keywords for this news article include: New Haven, Connecticut, United States, Stem Cell Research, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Stem Cell Week


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