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Researchers at Okayama University Graduate School of Medicine Target Peritoneal Fibrosis

May 14, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Digestive System Diseases and Conditions. According to news originating from Okayama, Japan, by NewsRx correspondents, research stated, "Long-term peritoneal dialysis (PD) causes chronic peritoneal damage. Peritoneal mesothelial cells (PMCs) play an important role in peritoneal function."

Our news journalists obtained a quote from the research from the Okayama University Graduate School of Medicine, "We investigated the possibility of cell therapy using the PMCs to prevent peritoneal damage in PD patients. We harvested human PMCs from the PD effluent of PD patients. The PMCs were separated based on morphological characteristics into epithelial-like (Epi) cells and fibroblast-like (Fib) cells by the limiting dilution method. We transplanted these cells into nude mice whose parietal and visceral peritoneum were scratched by mechanical scraping. The transplanted cells were detected at the parietal and visceral peritoneum. Compared with the positive control, the Epi cell therapy group showed very few adhesions and exhibited no thickening of the parietal and visceral peritoneum. However, the group with Fib cell therapy could not inhibit peritoneal adhesion and thickening. In addition, hepatocyte growth factor was expressed by the grafted Epi cells but not Fib cells. Fib cells expressed vascular endothelial growth factor stronger than Epi cells. These two types of cells from the same patient showed different characteristics and effects for cell therapy. These findings suggest that the PMCs from the PD patient showed different characteristics, such as Epi cells and Fib cells, and the selection of PMCs is important for cell therapy on the point of not only the direct cellular interactions but also cytokine secretion from the grafted cells."

According to the news editors, the research concluded: "Furthermore, the differences in the morphological cell characteristics may influence their role in peritoneal regeneration."

For more information on this research see: The selection of peritoneal mesothelial cells is important for cell therapy to prevent peritoneal fibrosis. Tissue Engineering Part a, 2014;20(3-4):529-39 (see also Digestive System Diseases and Conditions).

The news correspondents report that additional information may be obtained from S. Kitamura, Dept. of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama, Japan. Additional authors for this research include N. Horimoto, K. Tsuji, A. Inoue, K. Takiue, H. Sugiyama and H. Makino.

Keywords for this news article include: Asia, Biotechnology, Japan, Okayama, Cell Therapy, Biological Therapy, Peritoneal Diseases, Peritoneal Fibrosis, Digestive System Diseases and Conditions.

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Source: Biotech Week

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