News Column

Researchers at Mayo Clinic Report New Data on Bioinformatics

May 13, 2014

By a News Reporter-Staff News Editor at Information Technology Newsweekly -- A new study on Bioinformatics is now available. According to news reporting originating in Rochester, Minnesota, by VerticalNews journalists, research stated, "Reference genome assemblies are subject to change and refinement from time to time. Generally, researchers need to convert the results that have been analyzed according to old assemblies to newer versions, or vice versa, to facilitate meta-analysis, direct comparison, data integration and visualization."

The news reporters obtained a quote from the research from Mayo Clinic, "Several useful conversion tools can convert genome interval files in browser extensible data or general feature format, but none have the functionality to convert files in sequence alignment map or BigWig format. This is a significant gap in computational genomics tools, as these formats are the ones most widely used for representing high-throughput sequencing data, such as RNA-seq, chromatin immunoprecipitation sequencing, DNA-seq, etc. Here we developed CrossMap, a versatile and efficient tool for converting genome coordinates between assemblies."

According to the news reporters, the research concluded: "CrossMap supports most of the commonly used file formats, including BAM, sequence alignment map, Wiggle, BigWig, browser extensible data, general feature format, gene transfer format and variant call format."

For more information on this research see: CrossMap: a versatile tool for coordinate conversion between genome assemblies. Bioinformatics, 2014;30(7):1006-1007. Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press -; Bioinformatics -

Our news correspondents report that additional information may be obtained by contacting H. Zhao, Mayo Clinic, Dept. of Biochem & Mol Biol, Coll Med, Rochester, MN 55905, United States. Additional authors for this research include Z.F. Sun, J. Wang, H.J. Huang, J.P. Kocher and L.G. Wang.

Keywords for this news article include: Rochester, Minnesota, United States, Bioinformatics, North and Central America

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Source: Information Technology Newsweekly

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