By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Porous Silicon. According to news reporting originating from Brooklyn, New York, by NewsRx correspondents, research stated, "Colloidal solid dispersion is an innovative breakthrough in the pharmaceutical industry that overcomes the solubility-related issue of poorly soluble drugs by using an amorphous approach and also the stability-related issue by means of a complex formation phenomenon using different carrier materials. In the present study, a newly developed adsorption method is introduced to incorporate a high-energy sulfathiazole-polyvinylpyrrolidone (PlasdoneŽ K-29/32) solid dispersion on porous silicon dioxide (SyloidŽ 244FP)."
Our news editors obtained a quote from the research from the Arnold and Marie Schwartz College of Pharmacy and Health Sciences, "Different ternary systems of sulfathiazole-PlasdoneŽ K-29/32-SyloidŽ 244FP were prepared (1:1:2, 1:1:3, and 1:2:2) and categorized depending on the mechanism by which SyloidŽ 244FP was incorporated. Modulated differential scanning calorimetry (MDSC), X-ray diffraction, Fourier transform infrared spectroscopy, and in vitro dissolution studies were conducted to characterize the ternary systems. The X-ray diffraction and MDSC data showed a lack of crystallinity in all internal and external ternary systems, suggesting a loss of the crystallinity of sulfathiazole compared to the physical mixtures. USP apparatus II was used to measure the in vitro dissolution rate of the prepared systems at 75 rpm in different media. The dissolution rate of the optimum ratio (1:2:2) containing an internal ternary solid dispersion system was found to be three times higher than that of the external and physical systems."
According to the news editors, the research concluded: "Thus, the porous silicon dioxide incorporated into the conventional binary solid dispersion acted as a carrier to disperse the complex and increase the dissolution rate."
For more information on this research see: Evaluation of colloidal solid dispersions: physiochemical considerations and in vitro release profile. Aaps Pharmscitech [electronic Resource], 2013;14(2):620-8. Aaps Pharmscitech [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Porous Silicon).
The news editors report that additional information may be obtained by contacting V.I. Patel, Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, 75 Dekalb Avenue, HS Building 605, Brooklyn, NY 11201, United States.
Publisher contact information for the journal Aaps Pharmscitech [electronic Resource] is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Brooklyn, New York, Sulfones, Chemistry, United States, Nanotechnology, Porous Silicon, Sulfanilamides, Sulfathiazoles, Silicon Dioxide, Sulfur Compounds, Organic Chemicals, Emerging Technologies, North and Central America.
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