By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Life Science Research. According to news reporting originating from Bengal, India, by NewsRx correspondents, research stated, "Herein, an aqueous solution of etherified locust bean polysaccharide (ELBP) containing lamivudine was reticulated in presence of trivalent aluminium (Al3+) ions to nanoscale level (43.82-197.70 nm) by surfactant assisted homogenization-reticulation technique. The variation in aluminium chloride (AlCl3) strength (1.5-3.5% (w/v)) and drug:ELBP weight ratio (0.11-0.43) affected the properties of the nanoreticulations."
Our news editors obtained a quote from the research from Jadavpur University, "Regardless of the variables, a maximum of similar to 44% drug entrapment efficiency was noted. In simulated intestinal fluid (phosphate buffer solution, pH 7.4), the drug release rate was inversely proportional to the strength of AlCl3; but followed a proportional relationship with the drug: ELBP ratio. The mechanism of drug release shifted from Fickian diffusion to anomalous transport as the salt strength was increased above 2.5% (w/v). At intermediate drug:ELBP ratio, the drug release rate was regulated by polymer chain relaxation as opposed to simple diffusion mechanism. Fourier transform infrared spectroscopy did not show any evidence of chemical interaction between the drug and ELBP. Thermal analysis and X-ray diffraction studies suggested amorphous dispersion of drug in the nanoreticulations."
According to the news editors, the research concluded: "Thus, the nanoreticulations were expected to absorb via intestine and phagocytosed by the virus-infected hepatic macrophages and hence could be useful for controlled delivery of lamivudine avoiding dose-dependent toxicity of the drug."
For more information on this research see: Nanoreticulations of etherified locust bean polysaccharide for controlled oral delivery of lamivudine. International Journal of Biological Macromolecules, 2014;65():193-199. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
The news editors report that additional information may be obtained by contacting S. Maiti, Jadavpur University, Center Adv Res Pharmaceut Sci, Dept. of Pharmaceut Technol, Kolkata 700032, W Bengal, India. Additional authors for this research include R. Mondol and B. Sa (see also Life Science Research).
Keywords for this news article include: Asia, India, Bengal, Life Science Research
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