By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting from Tianjin, People's Republic of China, by NewsRx journalists, research stated, "Intervertebral discs (IVDs) are structurally complex tissue that hold the vertebrae together and provide mobility to spine. The nucleus pulposus (NP) degeneration often results in degenerative IVD disease that is one of the most common causes of back and neck pain."
The news correspondents obtained a quote from the research from Nankai University, "Tissue engineered nucleus pulposus offers an alternative approach to regain the function of the degenerative IVD. The aim of this study is to determine the feasibility of porous silk fibroin (SF) scaffolds fabricated by paraffin-sphere-leaching methods with freeze-drying in the application of nucleus pulposus regeneration. The prepared scaffold possessed high porosity of 92.38 +/- 5.12% and pore size of 165.00 +/- 8.25 mu m as well as high pore interconnectivity and appropriate mechanical properties. Rabbit NP cells were seeded and cultured on the SF scaffolds. Scanning electron microscopy, histology, biochemical assays and mechanical tests revealed that the porous scaffolds could provide an appropriate microstructure and environment to support adhesion, proliferation and infiltration of NP cells in vitro as well as the generation of extracellular matrix. The NP cell-scaffold construction could be preliminarily formed after subcutaneously implanted in a nude mice model."
According to the news reporters, the research concluded: "The SF porous scaffold offers a potential candidate for tissue engineered NP tissue."
For more information on this research see: Silk fibroin porous scaffolds for nucleus pulposus tissue engineering. Materials Science & Engineering C-Materials for Biological Applications, 2014;37():232-240. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Proteins).
Our news journalists report that additional information may be obtained by contacting C. Zeng, Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, People's Republic of China. Additional authors for this research include Q. Yang, M.F. Zhu, L.L. Du, J.M. Zhang, X.L. Ma, B.S. Xu and L.Y. Wang.
Keywords for this news article include: Asia, Tissue Engineering, Tianjin, Proteins, People's Republic of China
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