By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Nanoparticles. According to news reporting originating in New Delhi, India, by NewsRx journalists, research stated, "To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by investigating their intraocular retention by gamma-scintigraphy and intraocular pressure reduction. Carteolol (CRT) loaded CS-NPs were prepared by ionotropic gelation method."
The news reporters obtained a quote from the research from the Institute of Nuclear Medicine and Allied Sciences, "A four-factor three-level Box-Behnken design was employed to investigate the influence of independent variables on particle size, loading capacity and entrapment efficiency. Characterization was done for particle size, encapsulation efficiency, loading capacity and in vitro drug release and transcorneal permeation, histopathology and confocal microscopy, in vitro ocular tolerance. Intraocular retention was assessed by gamma-scintigraphy, and intraocular pressure was measured by tonometer betamethasone induced glaucoma rabbits. The optimized nanoparticles showed a particle size of 243 nm (PDI - 0.304 +/- 0.04) and drug loading 49.21 +/- 2.73% with entrapment efficiency of 69.57 +/- 3.54%. In vitro release studies showed a sustained release for 24 h as compared to drug solution. Ex vivo studies showed good permeation with non-significant changes in cornea anatomy indicating its safe nature. gamma-Scintigraphy study showed good spread and retention (
According to the news reporters, the research concluded: "These results indicate that CS nanoparticles are promising vehicles of CRT for ocular drug delivery."
For more information on this research see: Chitosan nanoparticles amplify the ocular hypotensive effect of cateolol in rabbits. International Journal of Biological Macromolecules, 2014;65():479-491. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
Our news correspondents report that additional information may be obtained by contacting A.m.e.e.d.u.z.z.a.f.a.r., .I.n.s.t. Nucl Med & Allied Sci, Dept. of Nucl Med, New Delhi, India. Additional authors for this research include J. Ali, A. Bhatnagar, N. Kumar and A. Ali (see also Nanoparticles).
Keywords for this news article include: Asia, India, Therapy, New Delhi, Nanotechnology, Drug Delivery Systems, Emerging Technologies
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