By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Drugs and Therapies. According to news reporting out of Bloomington, Indiana, by NewsRx editors, research stated, "Moderate exercise in the form of treadmill training and brief electrical nerve stimulation both enhance axon regeneration after peripheral nerve injury. Different regimens of exercise are required to enhance axon regeneration in male and female mice (Wood et al.: Dev Neurobiol 72 (2012) 688-698), and androgens are suspected to be involved."
Our news journalists obtained a quote from the research from Indiana University, "We treated mice with the androgen receptor blocker, flutamide, during either exercise or electrical stimulation, to evaluate the role of androgen receptor signaling in these activity-based methods of enhancing axon regeneration. The common fibular (CF) and tibial (TIB) nerves of thy-1-YFP-H mice, in which axons in peripheral nerves are marked by yellow fluorescent protein (YFP), were transected and repaired using CF and TIB nerve grafts harvested from non-fluorescent donor mice. Silastic capsules filled with flutamide were implanted subcutaneously to release the drug continuously. Exercised mice were treadmill trained 5 days/week for 2 weeks, starting on the third day post-transection. For electrical stimulation, the sciatic nerve was stimulated continuously for 1 h prior to nerve transection. After 2 weeks, lengths of YFP+ profiles of regenerating axons were measured from harvested nerves. Both exercise and electrical stimulation enhanced axon regeneration, but this enhancement was blocked completely by flutamide treatments."
According to the news editors, the research concluded: "Signaling through androgen receptors is necessary for the enhancing effects of treadmill exercise or electrical stimulation on axon regeneration in cut peripheral nerves."
For more information on this research see: Enhancement of peripheral nerve regeneration due to treadmill training and electrical stimulation is dependent on androgen receptor signaling. Developmental Neurobiology, 2014;74(5):531-540. Developmental Neurobiology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Developmental Neurobiology - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1932-846X)
Our news journalists report that additional information may be obtained by contacting N.J. Thompson, Indiana University, Dept. of Psychol & Brain Sci, Bloomington, IN, United States. Additional authors for this research include D.R. Sengelaub and A.W. English (see also Drugs and Therapies).
Keywords for this news article include: Indiana, Hormones, Bloomington, United States, Steroid Receptors, Androgen Receptors, Drugs and Therapies, DNA-Binding Proteins, Transcription Factors, North and Central America, Androgens and Anabolic Steroids
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