News Column

New Findings on Carrier Proteins Described by Investigators at Sun Yat Sen University

May 13, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Proteins. According to news reporting originating from Guangdong, People's Republic of China, by NewsRx correspondents, research stated, "We reported a novel mono-beta-cyclodextrin derivative, mono-6-deoxy-6-biguanidino-beta-cyclodextrin (beta-biGCD), which was investigated as a mimic of ADP/ATP carrier (AAC). Its affinity toward AMP, ADP, and ATP was evaluated by means of isothermal titration calorimetry (ITC)."

Our news editors obtained a quote from the research from Sun Yat Sen University, "The association constants (K-a) of beta-biGCD binding to AMP, ADP, and ATP were determined to be (1.07 +/- 0.04)x10(6), (5.86 +/- 0.02)x10(6), and (4.33 +/- 0.06)x10(6) L mo1(-1), respectively, which were 100-fold higher than mono-guanidino-beta-cyclodextrin (ca. 10(4) L mo1(-1)). UV spectroscopic titrations further confirmed the above results. The interaction between beta-biGCD and nucleotides was probed by docking simulation."

According to the news editors, the research concluded: "These results reveal that the biguanidinium moiety mimics the arginine residues of mitochondrial AAC protein."

For more information on this research see: beta-Biguanidinium-cyclodextrin: a supramolecular mimic of mitochondrial ADP/ATP carrier protein. Tetrahedron, 2014;70(14):2378-2382. Tetrahedron can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Tetrahedron - www.elsevier.com/wps/product/cws_home/942)

The news editors report that additional information may be obtained by contacting H.Y. Chen, Sun Yat Sen UniversitySch Pharmaceut Sci, Guangzhou 510080, Guangdong, People's Republic of China. Additional authors for this research include M. Zhao, J.H. Tan, Z.S. Huang, G.F. Liu, L.N. Ji and Z.W. Mao (see also Proteins).

Keywords for this news article include: Asia, Guangdong, Nanotechnology, Supramolecular, Carrier Proteins, Emerging Technologies, People's Republic of China

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Source: Life Science Weekly