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New Cell Proliferation Study Results from University of Basque Country Described

May 13, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Cell Proliferation. According to news reporting out of Bilbao, Spain, by NewsRx editors, research stated, "Picosecond laser micromachining technology (PLM) has been employed as a tool for the fabrication of 3D structured substrates. These substrates have been used as supports in the in vitro study of the effect of substrate topography on cell behavior."

Our news journalists obtained a quote from the research from the University of Basque Country, "Different micropatterns were PLM-generated on polystyrene (PS) and poly-L-lactide (PLLA) and employed to study cellular proliferation and morphology of breast cancer cells. The laser-induced microstructures included parallel lines of comparable width to that of a single cell (which in this case is roughly 20 mu m), and the fabrication of square-like compartments of a much larger area than a single cell (250,000 mu m(2)). The results obtained from this in vitro study showed that though the laser treatment altered substrate roughness, it did not noticeably affect the adhesion and proliferation of the breast cancer cells. However, pattern direction directly affected cell proliferation, leading to a guided growth of cell clusters along the pattern direction. When cultured in square-like compartments, cells remained confined inside these for eleven incubation days."

According to the news editors, the research concluded: "According to these results, laser micromachining with ultra-short laser pulses is a suitable method to directly modify the cell microenvironment in order to induce a predefined cellular behavior and to study the effect of the physical microenvironment on cell proliferation."

For more information on this research see: Ultra-fast laser microprocessing of medical polymers for cell engineering applications. Materials Science & Engineering C-Materials for Biological Applications, 2014;37():241-250. Materials Science & Engineering C-Materials for Biological Applications can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Cell Proliferation).

Our news journalists report that additional information may be obtained by contacting R. Ortiz, Univ Basque Country EHU UPV, Sch Engn, Dept. of Min & Met Engn Mat Sci, Bilbao 48013, Spain. Additional authors for this research include S. Moreno-Flores, I. Quintana, M. Vivanco, J.R. Sarasua and J.L. Toca-Herrera.

Keywords for this news article include: Spain, Bilbao, Europe, Engineering, Cell Proliferation

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Source: Cancer Weekly

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