By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Adenocarcinomas have been published. According to news originating from Dalian, People's Republic of China, by NewsRx correspondents, research stated, "To improve the efficacy of drug delivery, active targeted nanotechnology-based drug delivery systems are gaining considerable attention as they have the potential to reduce side effects, minimize toxicity, and improve efficacy of anticancer treatment. In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells."
Our news journalists obtained a quote from the research from Dalian Medical University, "These CUR-encapsulated bioconjugates (Apt-CUR-NPs) were characterized for particle size, zeta potential, drug encapsulation, stability, and release. The in vitro specific cell binding, cellular uptake, and cytotoxicity of Apt-CUR-NPs were also studied. The Apt-CUR-NP bioconjugates exhibited increased binding to HT29 colon cancer cells and enhancement in cellular uptake when compared to CUR-NPs functionalized with a control Apt (p
According to the news editors, the research concluded: "Further development of CUR-encapsulated, nanosized carriers will lead to improved targeted delivery of novel chemotherapeutic agents to colorectal cancer cells."
For more information on this research see: Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. International Journal of Nanomedicine, 2014;9():1083-96 (see also Adenocarcinomas).
The news correspondents report that additional information may be obtained from L. Li, College of Pharmacy, Dalian Medical University, Dalian, People's Republic of China. Additional authors for this research include D. Xiang, S. Shigdar, W. Yang, Q. Li, J. Lin, K. Liu and W. Duan.
Keywords for this news article include: Asia, Dalian, Cancer, Therapy, Oncology, Colorectal, Immunology, Nanoparticle, Nanotechnology, Adenocarcinomas, Epithelial Cells, Gastroenterology, Surface Antigens, Drug Delivery Systems, Emerging Technologies, Membrane Glycoproteins, Cell Adhesion Molecules, People's Republic of China.
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