By a News Reporter-Staff News Editor at Women's Health Weekly -- Investigators publish new report on Oncology. According to news reporting out of Tamil Nadu, India, by NewsRx editors, research stated, "This study was to investigate 'smart' pH-responsive drug delivery system (DDS) based on chitosan nano-carrier for its potential intelligent controlled release and enhancing chemotherapeutic efficiency of Oxalipaltin. Oxaliplatin was loaded onto chitosan by forming complexes with degradable to construct nano-carrier as a DDS."
Our news journalists obtained a quote from the research from Periyar University, "Oxaliplatin was released from the DDS much more rapidly at pH 4.5 than at pH 7.4, which is a desirable characteristic for tumor-targeted drug delivery. Furthermore, the possible intrinsic apoptotic signaling pathway was explored by Western blot. It was found that expression of Bax, Bik, cytochrome C, caspase-9 and -3 was significantly up-regulated while the Bcl-2 and Survivin were inhibited in breast cancer MCF-7 cells. For instance, nanoparticles inducing apoptosis in caspase-dependent manner indicate that chitosan nanoparticles could act as an efficient DDS importing Oxalipaltin to target cancer cells."
According to the news editors, the research concluded: "These approaches suggest that 'smart' Oxaliplatin delivery strategy is a promising approach to cancer therapy."
For more information on this research see: Oxaliplatin-chitosan nanoparticles induced intrinsic apoptotic signaling pathway: A "smart" drug delivery system to breast cancer cell therapy. International Journal of Biological Macromolecules, 2014;65():289-297. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
Our news journalists report that additional information may be obtained by contacting R. Vivek, Periyar Univ, Dept. of Zool, Salem, Tamil Nadu, India. Additional authors for this research include R. Thangam, V. Nipunbabu, T. Ponraj and S. Kannan (see also Oncology).
Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, India, Therapy, Oncology, Tamil Nadu, Oxaliplatin, Nanoparticle, Breast Cancer, Nanotechnology, Women's Health, Alkylating Agents, Drug Delivery Systems, Emerging Technologies
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