News Column

Data on Nanoporous Detailed by Researchers at Cancer Research Center

May 14, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Nanoporous have been published. According to news reporting out of Jinan, People's Republic of China, by NewsRx editors, research stated, "A 3D microfluidic electrochemical origami immunodevice (denoted as mu-ECOI in this work) for sensitive detection of tumor markers was designed. High sensitivity was achieved by using novel cuboid silver modified paper working electrode (CS-PWE) as sensor platform and different metal ions-coated nanoporous silver-chitosan (NSC) as labels."

Our news journalists obtained a quote from the research from Cancer Research Center, "The CS-PWE was fabricated through a seed-mediated growth approach and served as a promising platform for antibodies attachment. The metal ions could be detected directly through square wave voltammetry without metal preconcentration, and each biorecognition event produced a distinct voltammetric peak, whose position and size reflected the identity and amount of the corresponding antigen. The large number of metal ions loading on the NSC greatly amplified the detection signals, and the good biocompatibility of CS-PWE retained good stability for the sandwich-type immunoassay. Using cancer antigen 125 (CA125) and carcinoma antigen 199 (CA199) as model analytes, the simultaneous multiplex immunoassay showed linear ranges of over 4 orders of magnitude with the detection limits down to 0.02 and 0.04 mU mL(-1), respectively. Moreover, this strategy accurately detected the concentrations of CAl25 and CA199 in human serum samples. The detection limits of CA125 and CA199 were 0.08 and 0.10 mU mL(-1), respectively."

According to the news editors, the research concluded: "This facile biosensing mu-ECOI exhibited high sensitivity and specificity with excellent stability, reproducibility, and accuracy, indicating its wide range of potential applications in point-of-care testing."

For more information on this research see: Multiplex electrochemical origami immunodevice based on cuboid silver-paper electrode and metal ions tagged nanoporous silver-chitosan. Biosensors & Bioelectronics, 2014;56():167-173. Biosensors & Bioelectronics can be contacted at: Elsevier Advanced Technology, Oxford Fulfillment Centre The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biosensors & Bioelectronics -

Our news journalists report that additional information may be obtained by contacting W.P. Li, Shandong Tumor Hosp, Canc Res Center, Jinan 250117, People's Republic of China. Additional authors for this research include L. Li, S.G. Ge, X.R. Song, L. Ge, M. Yan and J.H. Yu (see also Nanoporous).

Keywords for this news article include: Asia, Jinan, Chemistry, Nanoporous, Nanotechnology, Electrochemical, Emerging Technologies, People's Republic of China

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Source: Biotech Week