News Column

Data on Fibroblasts Reported by Researchers at University of Illinois

May 13, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Fibroblasts is now available. According to news reporting from Urbana, Illinois, by NewsRx journalists, research stated, "Cell behavior in the presence of nanomaterials is typically explored through simple viability assays, but there is mounting evidence that nanomaterials can have more subtle effects on a variety of cellular functions. Previously our lab demonstrated that gold nanorods functionalized with polyelectrolyte multi-layers inhibited rat cardiac fibroblast-mediated remodeling of type I collagen scaffolds by altering fibroblast phenotype and the mechanical properties of the collagen network."

The news correspondents obtained a quote from the research from the University of Illinois, "In this work, we examine a possible mechanism for these effects: adsorption of cellular proteins by the nanorods. Mass spectrometric and gel electrophoresis of media collected from cultured cells suggests that a number of proteins, some of which mediate cell-cell and cell-matrix interactions, adsorb onto the surface of these nanoparticles in vitro. Polyethylene glycol coating of the nanorods largely mitigates protein adsorption and fibroblast-mediated collagen remodeling."

According to the news reporters, the research concluded: "These results suggest that adsorption of proteins by nanorods could have a significant effect on cell functions, including fibroblast-mediated matrix remodeling."

For more information on this research see: Adsorption of cellular proteins to polyelectrolyte-functionalized gold nanorods: a mechanism for nanoparticle regulation of cell phenotype? Plos One, 2014;9(2):e86670. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

Our news journalists report that additional information may be obtained by contacting P.N. Sisco, Dept. of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States. Additional authors for this research include C.G. Wilson, D. Chernak, J.C. Clark, E.M. Grzincic, K. Ako-Asare, E.C. Goldsmith and C.J Murphy (see also Fibroblasts).

Keywords for this news article include: Urbana, Illinois, Collagen, Peptides, Amino Acids, Fibroblasts, United States, Connective Tissue Cells, North and Central America, Extracellular Matrix Proteins.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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