News Column

Reports on General Science Findings from University of Delaware Provide New Insights

June 6, 2014

By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Science are presented in a new report. According to news originating from Newark, Delaware, by NewsRx correspondents, research stated, "The solution self-assembly of macromolecular amphiphiles offers an efficient, bottom-up strategy for producing well-defined nanocarriers, with applications ranging from drug delivery to nanoreactors. Typically, the generation of uniform nanocarrier architectures is controlled by processing methods that rely on cosolvent mixtures."

Our news journalists obtained a quote from the research from the University of Delaware, "These preparation strategies hinge on the assumption that macromolecular solution nanostructures are kinetically stable following transfer from an organic/aqueous cosolvent into aqueous solution. Herein we demonstrate that unequivocal step-change shifts in micelle populations occur over several weeks following transfer into a highly selective solvent. The unexpected micelle growth evolves through a distinct bimodal distribution separated by multiple fusion events and critically depends on solution agitation. Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein systems."

According to the news editors, the research concluded: "Moreover, the non-equilibrium micelle size increase can have a major impact on the assumed stability of solution assemblies, for which performance is dictated by nanocarrier size and structure."

For more information on this research see: Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway. Nature Communications, 2014;5():34-43. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Communications -

The news correspondents report that additional information may be obtained from E.G. Kelley, University of Delaware, Dept. of Chem & Biomol Engn, Newark, DE 19716, United States. Additional authors for this research include R.P. Murphy, J.E. Seppala, T.P. Smart, S.D. Hann, M.O. Sullivan and T.H. Epps (see also Science).

Keywords for this news article include: Newark, Science, Delaware, United States, North and Central America

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Source: Science Letter

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