News Column

Study Results from University of Montreal Broaden Understanding of DNA Research

June 3, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on DNA Research are presented in a new report. According to news originating from Montreal, Canada, by NewsRx correspondents, research stated, "We have designed programmable DNA-based nanoswitches whose closing/opening can be triggered over specific different pH windows. These nanoswitches form an intramolecular triplex DNA structure through pH-sensitive parallel Hoogsteen interactions."

Our news journalists obtained a quote from the research from the University of Montreal, "We demonstrate that by simply changing the relative content of TAT/CGC triplets in the switches, we can rationally tune their pH dependence over more than 5 pH units. The ability to design DNA-based switches with tunable pH dependence provides the opportunity to engineer pH nanosensors with unprecedented wide sensitivity to pH changes. For example, by mixing in the same solution three switches with different pH sensitivity, we developed a pH nanosensor that can precisely monitor pH variations over 5.5 units of pH."

According to the news editors, the research concluded: "With their fast response time (

For more information on this research see: Programmable pH-Triggered DNA Nanoswitches. Journal of the American Chemical Society, 2014;136(16):5836-5839. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Journal of the American Chemical Society -

The news correspondents report that additional information may be obtained from A. Idili, University of Montreal, Lab Biosensors & Nanomachines, Dept. of Chim, Montreal, PQ H3C 3J7, Canada. Additional authors for this research include A. Vallee-Belisle and F. Ricci (see also DNA Research).

Keywords for this news article include: Quebec, Canada, Montreal, DNA Research, North and Central America

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Source: Life Science Weekly

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