News Column

Study Results from NHS Foundation Trust in the Area of Peripheral Nerves Reported

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Peripheral Nervous System are presented in a new report. According to news originating from London, United Kingdom, by NewsRx correspondents, research stated, "Current commercially available nerve conduits fail to support nerve regeneration gaps larger than 30 mm in length due to the simple intra-luminal design of these conduits which are unable to biomimic the native neural environment. There is, therefore, a major clinical demand for new smart biomaterials, which can stimulate neuronal cell proliferation and migration, and facilitate nerve regeneration across these critical sized defects."

Our news journalists obtained a quote from the research from NHS Foundation Trust, "In this study, we aimed to investigate Schwann cell (SC) behaviour seeded on the bioabsorbable version of the nanocomposite material, POSS modified poly (caprolactone) urea urethane (PCL), functionalised with arginine-glycine-aspartic acid (RGD) peptide. Successful synthesis of RGD peptide as well as the chemical structure of POSS-PCL nanocomposite film was investigated by Fourier transform infrared spectroscopy. Cell viability assay and morphological assessment were performed to investigate the cytocompatibility of the fabricated constructs. Successful immobilisation of RGD peptide onto the nanocomposite surface was confirmed by water contact angle, Brilliant Blue (BB) staining and thin layer chromatography. Both POSS-PCL and RGD-POSS-PCL nanocomposite scaffolds supported SC attachment, proliferation and morphological differentiation, important aspects for peripheral nerve regeneration. However, a significant increase in SC process length and morphological differentiation towards maturation was observed on the cells grown on RGD-POSS-PCL film. RGD-POSS-PCL nanocomposite demonstrated a significant improvement in SCs spreading and its integrin-dependent process outgrowth (P < 0.05)."

According to the news editors, the research concluded: "Conduits made by POSS-nanocomposite may be suitable for the next generation of commercially available conduit required to meet current clinical demand in peripheral nerve regeneration and repair as they are currently undergoing in vivo preclinical study."

For more information on this research see: Investigation of Schwann cell behaviour on RGD-functionalised bioabsorbable nanocomposite for peripheral nerve regeneration. New Biotechnology, 2014;31(3):203-213. New Biotechnology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; New Biotechnology -

The news correspondents report that additional information may be obtained from T. Sedaghati, Royal Free London NHS Fdn Trust Hosp, London, United Kingdom. Additional authors for this research include G. Jell and A. Seifalian (see also Peripheral Nervous System).

Keywords for this news article include: London, Europe, Peptides, Proteins, Neuroglia, Proteomics, Schwann Cells, United Kingdom, Peripheral Nerves, Peripheral Nervous System

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Source: Biotech Week

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