News Column

Study Data from Ajou University Update Knowledge of Heparin Therapy

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Drugs and Therapies have been presented. According to news reporting originating from Suwon, South Korea, by NewsRx correspondents, research stated, "Specific genes and growth factors are involved in stem cell differentiation. In this study, we fabricated a delivery carrier for both protein and gene delivery that was introduced into human endothelial progenitor cells (EPCs)."

Our news editors obtained a quote from the research from Ajou University, "The highly negative charge carried by the heparin-modified pluronic nanogels allowed for binding to growth factors and localization in the core of nanogels. The residues of negatively charged heparin can complex with positively charged cationic materials, making it suitable for gene delivery. Supramolecular nanogels can be easily encapsulated the hydrophilic drugs and highly positive surfaces can be complexed with negative charge carrying plasmid DNA (pDNA). The size distribution, gel retardation, and denaturation of encapsulated growth factors and supramolecular nanogels modified with heparin were evaluated. The supramolecular nanogels containing basic fibroblast growth factors and complexing VEGF165 pDNA internalized into EPCs have been well formed vascular formation in matrigel gels. Proteins and genes introduced into EPCs using nanogels promoted neovascularization in an animal model of limb ischemia."

According to the news editors, the research concluded: "EPCs that differentiated into endothelial cells both in vitro and in vivo were tested."

For more information on this research see: Differentiation of endothelial progenitor cells into endothelial cells by heparin-modified supramolecular pluronic nanogels encapsulating bFGF and complexed with VEGF165 genes. Biomaterials, 2014;35(16):4716-4728. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

The news editors report that additional information may be obtained by contacting H.N. Yang, Ajou University, Dept. of Mol Sci & Technol, Suwon 443749, South Korea. Additional authors for this research include J.H. Choi, J.S. Park, S.Y. Jeon, K.D. Park and K.H. Park (see also Drugs and Therapies).

Keywords for this news article include: Asia, Suwon, Heparin, South Korea, Nanotechnology, Supramolecular, Endothelial Cells, Drugs and Therapies, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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