News Column

Studies from National Taipei University of Technology Have Provided New Data on Paracetamol Therapy

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Drugs and Therapies are discussed in a new report. According to news reporting originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "Highly loaded zirconium oxide (ZrO2) nanoparticles were supported on graphene oxide (ERGO/ZrO2) via an in situ, simple and clean strategy on the basis of the electrochemical redox reaction between zirconyl chloride and graphene oxide (ZrOCl2 and GO). The electrochemical measurements and surface morphology of the as prepared nanocomposite were studied using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and field emission scanning electron microscopy (FESEM)."

Our news editors obtained a quote from the research from the National Taipei University of Technology, "This ZrO2 decorated reduced graphene oxide nanocomposite modified GCE (ERGO/ZrO2) exhibits a prominent electrocatalytic activity toward the selective detection and determination of dopamine (DA) and paracetamol (PA) in presence of ascorbic acid (AA). The peaks of linear sweep voltammetry (LSV) for DA and PA oxidation at ERGO/ZrO2 modified electrode surface were clearly separated from each other when they co-existed in the physiological pH (pH 7.0) with a potential value of 140 mV (between M and DA) and 330 mV (between AA and PA). It was, therefore, possible to simultaneously determine DA and PA in the samples at ERGO/ZrO2 nanocomposite modified GCE. Linear calibration curves were obtained for 9-237 mu M of PA and DA."

According to the news editors, the research concluded: "The ERGO/ZrO2 nanocomposite electrode has been satisfactorily used for the determination of DA and PA in the presence of AA at pharmaceutical formulations in human urine samples with a linear range of 3-174 mu M. The proposed biosensor shows a wide linear range, low detection limit, good reproducibility and acceptable stability, providing a biocompatible platform for bio sensing and bio catalysis."

For more information on this research see: In situ electrochemical synthesis of highly loaded zirconium nanoparticles decorated reduced graphene oxide for the selective determination of dopamine and paracetamol in presence of ascorbic acid. Colloids and Surfaces B-Biointerfaces, 2014;115():295-301. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Drugs and Therapies).

The news editors report that additional information may be obtained by contacting A.T.E. Vilian, National Taipei University of Technology, Dept. of Chem Engn & Biotechnol, Electroanal & Bioelectrochem Lab, Taipei 106, Taiwan. Additional authors for this research include M. Rajkumar and S.M. Chen.

Keywords for this news article include: Asia, Taipei, Taiwan, Chemistry, Paracetamol, Sugar Acids, Nanoparticle, Ascorbic Acid, Nanotechnology, Electrochemical, Drugs and Therapies, Emerging Technologies

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Source: Biotech Week

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