By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Amino Acids. According to news reporting originating in Tianjin, People's Republic of China, by NewsRx journalists, research stated, "D-peptides, which consist of D-amino acids and can resist the hydrolysis catalyzed by endogenous peptidases, are one of the promising candidates for construction of peptide materials with enhanced biostability in vivo. In this paper, we report on a self-assembling supramolecular nanostructure of D-amino acid-based peptide Nap-G(D)F(D)F(D)YGRGD (D-fiber, F-D meant D-phenylalanine, Y-D meant D-tyrosine), which were used as carriers for 10-hydroxycamptothecin (HCPT)."
The news reporters obtained a quote from the research from Nankai University, "Transmission electron microscopy observations demonstrated the filamentous morphology of the HCPT-loaded peptides (D-fiber-HCPT). The better selectivity and antitumor activity of D-fiber-HCPT than L-fiber-HCPT were found in the in vitro and in vivo antitumor studies."
According to the news reporters, the research concluded: "These results highlight that this model D-fiber system holds great promise as vehicles of hydrophobic drugs for cancer therapy."
For more information on this research see: Self-Assembling Peptide of D-Amino Acids Boosts Selectivity and Antitumor Efficacy of 10-Hydroxycamptothecin. ACS Applied Materials & Interfaces, 2014;6(8):5558-5565. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news correspondents report that additional information may be obtained by contacting J.F. Liu, Nankai Univ, Collaborat Innovat Center Chem Sci & Engn Tianjin, Tianjin 300071, People's Republic of China. Additional authors for this research include J.J. Liu, L.P. Chu, Y.M. Zhang, H.Y. Xu, D.L. Kong, Z.M. Yang, C.H. Yang and D. Ding (see also Amino Acids).
Keywords for this news article include: Asia, Tianjin, Therapy, Peptides, Proteins, Amino Acids, People's Republic of China
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