News Column

Studies from L.N. Lili and Co-Researchers Update Current Data on Cancer Gene Therapy

June 2, 2014



By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Researchers detail new data in Biotechnology. According to news originating from Newnan, Georgia, by NewsRx correspondents, research stated, "There is a growing body of evidence that targeted gene therapy holds great promise for the future treatment of cancer. A crucial step in this therapy is the accurate identification of appropriate candidate genes/pathways for targeted treatment."

Our news journalists obtained a quote from the research, "One approach is to identify variant genes/pathways that are significantly enriched in groups of afflicted individuals relative to control subjects. However, if there are multiple molecular pathways to the same cancer, the molecular determinants of the disease may be heterogeneous among individuals and possibly go undetected by group analyses. In an effort to explore this question in pancreatic cancer, we compared the most significantly differentially expressed genes/pathways between cancer and control patient samples as determined by group versus personalized analyses. We found little to no overlap between genes/pathways identified by gene expression profiling using group analyses relative to those identified by personalized analyses."

According to the news editors, the research concluded: "Our results indicate that personalized and not group molecular profiling is the most appropriate approach for the identification of putative candidates for targeted gene therapy of pancreatic and perhaps other cancers with heterogeneous molecular etiology."

For more information on this research see: Evidence for the Importance of Personalized Molecular Profiling in Pancreatic Cancer. Pancreas, 2014;43(2):198-211. Pancreas can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Pancreas - journals.lww.com/pancreasjournal/pages/default.aspx)

The news correspondents report that additional information may be obtained from L.N. Lili, Canc Treatment Center Amer SE Reg Facil, Newnan, GA, United States. Additional authors for this research include L.V. Matyunina, L.D. Walker, G.W. Daneker and J.F. McDonald (see also Biotechnology).

Keywords for this news article include: Biotechnology, Pharmaceuticals, Newnan, Georgia, Genetics, Oncology, United States, Bioengineering, Gastroenterology, Pancreatic Cancer, Cancer Gene Therapy, Pancreatic Neoplasms, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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