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Studies from D.Q. Zheng and Co-Researchers Yield New Data on Applied microbiology and biotechnology

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting from Nanyang, People's Republic of China, by NewsRx journalists, research stated, "Whole-genome shuffling (WGS) is a powerful technology of improving the complex traits of many microorganisms. However, the molecular mechanisms underlying the altered phenotypes in isolates were less clarified."

The news correspondents obtained a quote from the research, "Isolates with significantly enhanced stress tolerance and ethanol titer under very-high-gravity conditions were obtained after WGS of the bioethanol Saccharomyces cerevisiae strain ZTW1. Karyotype analysis and RT-qPCR showed that chromosomal rearrangement occurred frequently in genome shuffling. Thus, the phenotypic effects of genomic structural variations were determined in this study. RNA-Seq and physiological analyses revealed the diverse transcription pattern and physiological status of the isolate S3-110 and ZTW1. Our observations suggest that the improved stress tolerance of S3-110 can be largely attributed to the copy number variations in large DNA regions, which would adjust the ploidy of yeast cells and expression levels of certain genes involved in stress response."

According to the news reporters, the research concluded: "Overall, this work not only constructed shuffled S. cerevisiae strains that have potential industrial applications but also provided novel insights into the molecular mechanisms of WGS and enhanced our knowledge on this useful breeding strategy."

For more information on this research see: Genomic structural variations contribute to trait improvement during whole-genome shuffling of yeast. Applied Microbiology and Biotechnology, 2014;98(7):3059-3070. Applied Microbiology and Biotechnology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Applied Microbiology and Biotechnology -

Our news journalists report that additional information may be obtained by contacting D.Q. Zheng, Tianguan Grp Co Ltd, State Key Lab Motor Vehicle Biofuel Technol, Nanyang 473000, Henan Province, People's Republic of China. Additional authors for this research include J. Chen, K. Zhang, K.H. Gao, O. Li, P.M. Wang, X.Y. Zhang, F.G. Du, P.Y. Sun, A.M. Qu, S. Wu and X.C. Wu (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Nanyang, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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