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Researchers from University of Washington Detail New Studies and Findings in the Area of Gene Therapy

June 5, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Data detailed on Biotechnology have been presented. According to news reporting out of Seattle, Washington, by NewsRx editors, research stated, "Ultrasound (US)-mediated gene delivery has emerged as a promising non-viral method for safe and selective gene delivery. When enhanced by the cavitation of microbubbles (MBs), US exposure can induce sonoporation that transiently increases cell membrane permeability for localized delivery of DNA."

Our news journalists obtained a quote from the research from the University of Washington, "The present study explores the effect of generalizable MB customizations on MB facilitation of gene transfer compared to Definity ,a clinically available contrast agent. These modifications are 1) increasedMB shell acyl chain length (RN18) for elevated stability and 2) addition of positive charge on MB (RC5K) for greater DNA associability. The MB typeswere compared in their ability to facilitate transfection of luciferase and GFP reporter plasmid DNA in vitro and in vivo under various conditions of US intensity, MB dosage, and pretreatment MB-DNA incubation. The results indicated that both RN18 and RC5K were more efficient than Definity , and that the cationic RC5K can induce even greater transgene expression by increasing payload capacity with prior DNA incubation without compromising cell viability. These findings could be applied to enhance MB functions in a wide range of therapeutic US/MB gene and drug delivery approach."

According to the news editors, the research concluded: "With further designs, MB customizations have the potential to advance this technology closer to clinical application."

For more information on this research see: Development of therapeutic microbubbles for enhancing ultrasound-mediated gene delivery. Journal of Controlled Release, 2014;182():111-120. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)

Our news journalists report that additional information may be obtained by contacting R.R. Sun, University of Washington, Dept. of Pediat, Seattle, WA 98195, United States. Additional authors for this research include M.L. Noble, S.S. Sun, S. Song and C.H. Miao (see also Biotechnology).

Keywords for this news article include: Biotechnology, Seattle, Washington, Ultrasound, DNA Research, Gene Therapy, United States, Bioengineering, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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