News Column

Researchers from Sun Yat Sen University Provide Details of New Studies and Findings in the Area of DNA Vaccines

June 2, 2014

By a News Reporter-Staff News Editor at Cancer Vaccine Week -- A new study on Biotechnology is now available. According to news reporting originating in Guangdong, People's Republic of China, by NewsRx journalists, research stated, "DNA-based tumor vaccine immunotherapy which elicits exclusively cellular immune response against cancer cells in an antigen-specific fashion has been documented to be an effective treatment for cancers in the past decade. Glypican 3 (GPC3) is especially overexpressed in hepatocellular carcinoma (HCC), but not in benign liver lesions and normal adult tissues, which makes it an ideal tumor antigen designed for HCC immunotherapy."

The news reporters obtained a quote from the research from Sun Yat Sen University, "We constructed a GPC3 cDNA vaccine by using a recombinant plasmid encoding murine GPC3 cDNA for treatment of HCC in a C57BL/6 mouse model. The specificity and effectiveness of anti-tumor immunity were assessed in vitro and in vivo studies. In vitro studies showed that GPC3 DNA vaccine induced potent specific cytotoxic T lymphoctyes (CTLs) immune response against C57BL/6 homogenous HCC cell line Hepa 1-6 (GPC3*). However, there was no detectable immune response against GPC3-negative SP 2/0 cells and Sk-Hep-1 cells. In vivo study indicated that GPC3 DNA vaccine could significantly suppress homogenous tumor growth and prolong survival time of tumor bearing mice. This study demonstrated the first time that the GPC3 DNA vaccine could elicit specific and effective cellular antitumor immunity against GPC3(+) HCC."

According to the news reporters, the research concluded: "This may provide an alternative option for immunotherapy of HCC."

For more information on this research see: GPC3 DNA Vaccine Elicits Potent Cellular Antitumor Immunity against HCC in Mice. Hepato-Gastroenterology, 2014;61(130):278-284. Hepato-Gastroenterology can be contacted at: H G E Update Medical Publishing S A, PO Box 17257, Athens Gr-10024, Greece. (Thieme -

Our news correspondents report that additional information may be obtained by contacting S.Q. Li, Sun Yat Sen UniversityAffiliated Hosp 1, Operating Center, Guangzhou 510080, Guangdong, People's Republic of China. Additional authors for this research include J. Lin, C.Y. Qi, S.J. Fu, W.K. Xiao, B.G. Peng and L.J. Liang (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Guangdong, DNA Research, DNA Vaccines, Immunotherapy, Tumor Vaccines, Immunomodulation, Synthetic Vaccines, Biological Products, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Vaccine Week

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