By a News Reporter-Staff News Editor at Biotech Week -- New research on Nanoparticles is the subject of a report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Intracellular protein delivery shows great promise in the treatment of various diseases. However, therapeutic applications of this method are limited by its low delivery efficiency and poor targeting ability."
The news correspondents obtained a quote from the research from the Beijing University of Chemical Technology, "As one of most important drug delivery cargoes, Fe3O4 nanoparticles (nFe(3)O(4)) have attracted much attention for both therapeutic and diagnostic applications, especially for targeting drug delivery. To use nFe(3)O(4) for protein delivery, a simple but effective modification of nFe(3)O(4) is critical to attach proteins on its surface. In this work, by designing and synthesizing cationic poly(2-(dimethylamino)ethyl methacrylate) (PDMA)-grafted nFe(3)O(4) via in situ atom transfer radical polymerization (ATRP), we demonstrate a simple solution to improve interactions between nFe(3)O(4) and proteins. With the grafted PDMA on the surface, nFe(3)O(4) exhibits not only significant enhancement in dispersibility and stability in aqueous phase, but also an excellent capability to attach negative-charged proteins. Moreover, with the assistance of external magnetic field, PDMA-grafted nFe(3)O(4) can be used as a targetable vector to deliver proteins into specific cells."
According to the news reporters, the research concluded: "This work provides a novel platform based on cationic magnetite nanoparticles that can deliver therapeutic proteins into specific sites for the treatment of various diseases."
For more information on this research see: Synthesis of Cationic Magnetite Nanoparticles for Intracellular Protein Delivery. Journal of Applied Polymer Science, 2014;131(10):402-408. Journal of Applied Polymer Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Polymer Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4628)
Our news journalists report that additional information may be obtained by contacting Z. Wang, Beijing University of Chemical Technology, State Key Lab Organ Inorgan Composites, Beijing 100029, People's Republic of China. Additional authors for this research include J.J. Zhang, R.D. Li and J.F. Chen (see also Nanoparticles).
Keywords for this news article include: Asia, Beijing, Therapy, Peptides, Proteins, Amino Acids, Nanotechnology, Drug Delivery Systems, Emerging Technologies, People's Republic of China
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