News Column

Research Conducted at Chinese Academy of Science Has Updated Our Knowledge about Materials Science

June 3, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on Materials Science are presented in a new report. According to news reporting originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "In recent years, many nanomaterials have been developed as drug carriers to overcome their low solubility. However, the poor drug loading (general < 5%) requires excessive use of carrier materials which may induce side effects and inhibit their clinical translation."

Our news editors obtained a quote from the research from the Chinese Academy of Science, "Herein, hydrophobic mesotetraphenylporphyrin (TPP) photosensitizer (PS) molecules are firstly assembled into pure nanocrystals by solvent exchange. Secondly, amphiphilic multidentate polymer ligand, PEG-grafted poly (maleic anhydride-alt-1-octadecene) (C18PMH-PEG), is modified on the nanocrystal surface to enhance their stability in saline. The as-prepared drug deliveiy system (DDS) by the two-step strategy significantly improves the drug loading (over 87%). The DDS shows high stability in saline and is engulfed by cancer cells."

According to the news editors, the research concluded: "Further study demonstrates that the DDS is an effective photodynamic therapeutic agent of cancer cells while the free PS molecules quickly precipitate without obvious destruction of cancer cells."

For more information on this research see: Carrier-free photosensitizer nanocrystal for photodynamic therapy. Materials Letters, 2014;122():323-326. Materials Letters can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Materials Letters -

The news editors report that additional information may be obtained by contacting F.F. An, Chinese Academy Sci, Technical Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, People's Republic of China. Additional authors for this research include Y.A. Li and J.F. Zhang (see also Materials Science).

Keywords for this news article include: Asia, Cancer, Beijing, Therapy, Oncology, Materials Science, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Weekly

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