News Column

Recent Studies from University of Georgia Add New Data to Poisoning

June 6, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Poisoning have been published. According to news reporting originating from Athens, Georgia, by NewsRx correspondents, research stated, "We have developed a thiol-modified nanoporous silica material (SH-SAMMS) as an oral therapy for the prevention and treatment of heavy metal poisoning. SH-SAMMS has been reported to be highly efficient at capturing heavy metals in biological fluids and water."

Our news editors obtained a quote from the research from the University of Georgia, "Herein, SH-SAMMS was examined for efficacy and safety in both in vitro and in vivo animal models for the oral detoxification of heavy metals. In simulated gastrointestinal fluids, SH-SAMMS had a very high affinity (K-d) for methyl mercury (MeHg(I)), inorganic mercury (Hg(II)), lead (Pb(II)), and cadmium (Cd(II)) and was superior to other SAMMS with carboxylic acid or phosphonic acid ligands or commercially available metal chelating sorbents. SH-SAMMS also effectively removed Hg from biologically digested fish tissue with no effect on most nutritional minerals found in fish. SH-SAMMS could hold Hg(II) and MeHg(I) tightly inside the nanosize pores, thus preventing bacteria from converting them to more absorbable forms. Rats fed a diet containing MeHg(I), Cd(II), and Pb(II) and SH-SAMMS for 2 weeks had blood Hg levels significantly lower than rats fed the metal-rich diet only. Upon cessation of the metal-rich diet, continued administration of SH-SAMMS for 2 weeks facilitated faster and more extensive clearance of Hg than in animals not continued on oral SH-SAMMS. Rats receiving SH-SAMMS also suffered less weight loss as a result of the metal exposure. Retention of Hg and Cd in major organs was lowest in rats fed with SH-SAMMS throughout the entire four weeks. The reduction of blood Pb by SH-SAMMS was significant. SH-SAMMS was safe to intestinal epithelium model (Caco-2) and common intestinal bacteria (Escherichia coli). Altogether, it has great potential as a new oral drug for the treatment of heavy metal poisoning."

According to the news editors, the research concluded: "This new application is enabled by the installation of tailored interfacial chemistry upon nontoxic nanoporous materials."

For more information on this research see: Novel Oral Detoxification of Mercury, Cadmium, And Lead with Thiol-Modified Nanoporous Silica. ACS Applied Materials & Interfaces, 2014;6(8):5483-5493. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

The news editors report that additional information may be obtained by contacting T. Sangvanich, University of Georgia, Dept. of Microbiol, Athens, GA 30602, United States. Additional authors for this research include J. Morry, C. Fox, W. Ngamcherdtrakul, S. Goodyear, D. Castro, G.E. Fryxell, R.S. Addleman, A.O. Summers and W. Yantasee (see also Poisoning).

Keywords for this news article include: Athens, Georgia, Cadmium, Poisoning, Nanoporous, Heavy Metals, United States, Nanotechnology, Transition Elements, Emerging Technologies, North and Central America

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Source: Health & Medicine Week


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