News Column

Recent Findings in Clinical Trials and Studies Described by Researchers from University of Texas

June 2, 2014

By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in Clinical Research. According to news originating from Richardson, Texas, by NewsRx correspondents, research stated, "Biocompatible dysprosia aerogels were synthesized from DyCl3 center dot 6H(2)O and were reinforced mechanically with a conformal nano-thin-polyurea coating applied over their skeletal framework. The random mesoporous space of dysprosia aerogels was filled up to about 30% v/v with paracetamol, indomethacin, or insulin, and the drug release rate was monitored spectrophotometrically in phosphate buffer (pH = 7.4) or 0.1 M aqueous HCl."

Our news journalists obtained a quote from the research from the University of Texas, "The drug uptake and release study was conducted comparatively with polyurea-crosslinked random silica aerogels, as well as with as-prepared (native) and polyurea-crosslinked mesoporous silica perforated with ordered 7 nm tubes in hexagonal packing. Drug uptake from random nanostructures (silica or dysprosia) was higher (30-35% w/w) and the release rate was slower (typically >20 h) relative to ordered silica (19-21% w/w,

According to the news editors, the research concluded: "The high drug uptake and slow release from dysprosia aerogels, in combination with their low toxicity, strong paramagnetism, and the possibility for neutron activation render those materials attractive multifunctional vehicles for site-specific drug delivery."

For more information on this research see: Evaluation of Dysprosia Aerogels as Drug Delivery Systems: A Comparative Study with Random and Ordered Mesoporous Silicas. ACS Applied Materials & Interfaces, 2014;6(7):4891-4902. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; ACS Applied Materials & Interfaces -

The news correspondents report that additional information may be obtained from A. Bang, Univ Texas Dallas, Dept. of Mech Engn, Richardson, TX 75080, United States. Additional authors for this research include A.G. Sadekar, C. Buback, B. Curtin, S. Acar, D. Kolasinac, W. Yin, D.A. Rubenstein, H.B. Lu, N. Leventis and C. Sotiriou-Leventis (see also Clinical Research).

Keywords for this news article include: Texas, Therapy, Richardson, United States, Clinical Research, Drug Delivery Systems, North and Central America, Clinical Trials and Studies

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Source: Clinical Trials Week

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