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Recent Findings from Central Leather Research Institute Has Provided New Information about Extracellular Matrix Proteins

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Proteins have been published. According to news originating from Tamil Nadu, India, by NewsRx correspondents, research stated, "Collagen is a promising biomaterial for drug delivery due to advantages including high biocompatibility and biodegradable property. However, transforming collagen into solid nanoparticles is difficult, although the solid dosage form is advantageous for some administration routes including pulmonary and oral drug delivery."

Our news journalists obtained a quote from the research from Central Leather Research Institute, "In this study, collagen solid nanoparticles are prepared in one-step using electrospray deposition under ambient temperature and pressure conditions. Although collagen molecules formed micron-sized aggregates in acetic acid solutions spontaneously, electrospraying the collagen solutions resulted in formation of nanofibers. Solid nanoparticles were obtained by increasing conductivity of the solution and/or inducing structural perturbation of the collagen molecules using salts. The ability of solid collagen particles as a drug carrier was demonstrated by incorporating theophylline as a model drug using a coaxial spray technique. Release of theophylline was controlled by cross-linking collagen molecules."

According to the news editors, the research concluded: "Electrospray deposition was proved to be a powerful method for producing solid collagen nanoparticles for drug delivery."

For more information on this research see: Fabrication of Solid Collagen Nanoparticles Using Electrospray Deposition. Chemical & Pharmaceutical Bulletin, 2014;62(5):422-428. Chemical & Pharmaceutical Bulletin can be contacted at: Pharmaceutical Soc Japan, 2-12-15 Shibuya, Shibuya-Ku, Tokyo, 150-0002, Japan (see also Proteins).

The news correspondents report that additional information may be obtained from U. Nagarajan, Cent Leather Res Inst, Council Sci & Ind Res, Chennai 600020, Tamil Nadu, India. Additional authors for this research include K. Kawakami, S.L. Zhang, B. Chandrasekaran and B.U. Nair.

Keywords for this news article include: Asia, India, Therapy, Collagen, Tamil Nadu, Nanoparticle, Nanotechnology, Drug Delivery Systems, Emerging Technologies, Extracellular Matrix Proteins

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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