By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Oncology. According to news reporting originating from Tamil Nadu, India, by NewsRx correspondents, research stated, "Targeted drug delivery using nanocrystalline materials delivers the drug at the diseased site. This increases the efficacy of the drug in killing the cancer cells."
Our news editors obtained a quote from the research from Anna University, "Surface modifications were done to target the drug to a particular receptor on the cell surface. This paper reports synthesis of hydroxyapatite and titanium dioxide nanoparticles and modification of their surface with polyethylene glycol (PEG) followed by folic acid (FA). Paclitaxel, an anticancer drug, is attached to functionalized hydroxyapatite and titanium dioxide nanoparticles. The pure and functionalised nanoparticles are characterised with XRD, TEM and UV spectroscopy. Anticancer analysis was carried out in DEN induced hepatocarcinoma animals. Biochemical, hematological and histopathological analysis show that the surface modified paclitaxel attached nanoparticles have an higher anticancer activity than the pure paclitaxel and surface modified nanoparticles without paclitaxel."
According to the news editors, the research concluded: "This is due to the targeting of the drug to the folate receptor in the cancer cells."
For more information on this research see: In vitro and in vivo anticancer activity of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles. Biomedical Microdevices, 2013;15(4):711-26. Biomedical Microdevices can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Biomedical Microdevices - www.springerlink.com/content/1387-2176/)
The news editors report that additional information may be obtained by contacting G.D. Venkatasubbu, Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India. Additional authors for this research include S. Ramasamy, G.P. Reddy and J. Kumar (see also Oncology).
Publisher contact information for the journal Biomedical Microdevices is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, India, Drugs, Taxoids, Therapy, Oncology, Terpenes, Chemistry, Tamil Nadu, Paclitaxel, Hydrocarbons, Nanoparticle, Cycloparaffins, Nanotechnology, Titanium Dioxide, Organic Chemicals, Mitotic Inhibitors, Emerging Technologies.
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