News Column

Patent Issued for Method and System for Setting Cardiac Resynchronization Therapy Parameters

June 2, 2014

By a News Reporter-Staff News Editor at Cardiovascular Week -- According to news reporting originating from Alexandria, Virginia, by NewsRx journalists, a patent by the inventors Ding, Jiang (Shoreview, MN); Yu, Yinghong (Shoreview, MN); KenKnight, Bruce H. (Maple Grove, MI), filed on January 10, 2011, was published online on May 20, 2014 (see also Cardiac Pacemakers, Inc.).

The assignee for this patent, patent number 8731660, is Cardiac Pacemakers, Inc. (St. Paul, MN).

Reporters obtained the following quote from the background information supplied by the inventors: "Cardiac rhythm management devices are implantable devices that provide electrical stimulation to selected chambers of the heart in order to treat disorders of cardiac rhythm. A pacemaker, for example, is a cardiac rhythm management device that paces the heart with timed pacing pulses. The most common condition for which pacemakers are used is in the treatment of bradycardia, where the ventricular rate is too slow. Atrio-ventricular conduction defects (i.e., AV block) that are permanent or intermittent and sick sinus syndrome represent the most common causes of bradycardia for which permanent pacing may be indicated. If functioning properly, the pacemaker makes up for the heart's inability to pace itself at an appropriate rhythm in order to meet metabolic demand by enforcing a minimum heart rate and/or artificially restoring AV conduction.

"Pacing therapy can also be used in the treatment of heart failure, which refers to a clinical syndrome in which an abnormality of cardiac function causes a below normal cardiac output that can fall below a level adequate to meet the metabolic demand of peripheral tissues. When uncompensated, it usually presents as congestive heart failure due to the accompanying venous and pulmonary congestion. Heart failure can be due to a variety of etiologies with ischemic heart disease being the most common. It has been shown that some heart failure patients suffer from intraventricular and/or interventricular conduction defects (e.g., bundle branch blocks) such that their cardiac outputs can be increased by improving the synchronization of ventricular contractions with electrical stimulation. In order to treat these problems, implantable cardiac devices have been developed that provide appropriately timed electrical stimulation to one or more heart chambers in an attempt to improve the coordination of atrial and/or ventricular contractions, termed cardiac resynchronization therapy (CRT). Ventricular resynchronization is useful in treating heart failure because, although not directly inotropic, resynchronization can result in a more coordinated contraction of the ventricles with improved pumping efficiency and increased cardiac output. Currently, a most common form of CRT applies stimulation pulses to both ventricles, either simultaneously or separated by a specified biventricular offset interval, and after a specified atrio-ventricular delay interval with respect to the detection of an intrinsic atrial contraction and/or an atrial pace. Appropriate specification of these pacing parameters is necessary in order to achieve optimum improvement in cardiac function, and it is this problem with which the present invention is primarily concerned."

In addition to obtaining background information on this patent, NewsRx editors also obtained the inventors' summary information for this patent: "The present invention relates to a method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data. Such intrinsic conduction data may be collected via the sensing channels of an implantable cardiac device and either utilized by the implantable device itself to compute optimal pacing parameters or transmitted to an external programmer via a wireless telemetry link. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder."

For more information, see this patent: Ding, Jiang; Yu, Yinghong; KenKnight, Bruce H.. Method and System for Setting Cardiac Resynchronization Therapy Parameters. U.S. Patent Number 8731660, filed January 10, 2011, and published online on May 20, 2014. Patent URL:

Keywords for this news article include: Therapy, Cardiology, Heart Disease, Heart Failure, Cardiac Pacemakers Inc., Cardiovascular Diseases.

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Source: Cardiovascular Week

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