By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Nanoparticles have been published. According to news reporting originating in Tianjin, People's Republic of China, by NewsRx journalists, research stated, "A one-pot synthesis is developed for PEG(600)-b-poly(glycerol monoacrylate) (PEG(600)-b-PGA), by which folate and superparamagnetic iron oxide nanoparticles (SPIONs) are assembled to form folic acid-conjugated magnetic nanoparticles (FA-MNPs) as a tumor targeting system. The synthesis consists of a click reaction and atom transfer radical polymerization (ATRP) to obtain the well-defined furan-protected maleimido-terminated PEG(600)-b-poly(solketal acrylate) (PEG(600)-b-PSA) copolymer."
The news reporters obtained a quote from the research, "After deprotection, the key copolymer N-maleimido-terminated PEG(600)-b-PGA is successfully conjugated with thiol derivatives of folate and FITC, respectively. FA-MNPs are developed by assembling of the resulting polymer FA-PEG(600)-b-PGA with SPIONs, and characterized for their size, surface charge, and superparamagnetic properties. To investigate the cellular uptake of the nanoparticles by Hela cells and phi 2 cells using fluoresce technique, FA-FITC-MNPs are also obtained by assembling of FA-PEG(600)-b-PGA, FITC-PEG(600)-b-PGA with SPIONs. Qualitative and quantitative determinations of FA-FITC-MNPs show that the particles specifically internalized to Hela cells."
According to the news reporters, the research concluded: "No significant cytotoxicity is observed for these two kinds of cell lines."
For more information on this research see: "One-Pot" Synthesis of Well-Defined Functional Copolymer and Its Application as Tumor-Targeting Nanocarrier in Drug Delivery. Journal of Applied Polymer Science, 2014;131(12):61-70. Journal of Applied Polymer Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Polymer Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4628)
Our news correspondents report that additional information may be obtained by contacting C.H. Wang, Collaborat Innovat Center Chem Sci & Engn Tianjin, Tianjin 300071, People's Republic of China. Additional authors for this research include L. Qiao, H.S. Yan and K.L. Liu (see also Nanoparticles).
Keywords for this news article include: Asia, Tianjin, Nanotechnology, Emerging Technologies, People's Republic of China
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