News Column

New Findings Reported from D. Clay and Co-Authors Describe Advances in Biotechnology

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- New research on Technology is the subject of a report. According to news originating from Graz, Austria, by NewsRx correspondents, research stated, "The bioreduction and disproportionation of cyclohex-2-enone catalyzed by Old Yellow Enzyme 1 was investigated in presence of organic (co)solvents. Whereas the NADH-dependent bioreduction activity strongly decreased at elevated co-solvent concentrations due to the insolubility of the nicotinamide-cofactor, the NADH-free disproportionation was significantly improved in water-immiscible organic co-solvents at 90 % (v/v) with near-quantitative conversion."

Our news journalists obtained a quote from the research, "This positive effect was attributed to removal of the inhibiting co-product, phenol, from the enzyme's active site. The best co-solvents show high lipophilicity (logP) and a high potential to solubilize phenol (K-phenol)."

According to the news editors, the research concluded: "As a predictive parameter, the ratio of logP/K-phenol should be preferably a parts per thousand yen100."

For more information on this research see: Bioreduction and disproportionation of cyclohex-2-enone catalyzed by ene-reductase OYE-1 in 'micro-aqueous' organic solvents. Biotechnology Letters, 2014;36(6):1329-1333. Biotechnology Letters can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer -; Biotechnology Letters -

The news correspondents report that additional information may be obtained from D. Clay, ACIB GmbH Co, Graz, Austria. Additional authors for this research include C.K. Winkler, G. Tasnadi and K. Faber (see also Technology).

Keywords for this news article include: Graz, Europe, Austria, Reductase, Technology, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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