By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Nanoparticles are discussed in a new report. According to news reporting originating in Hong Kong, People's Republic of China, by NewsRx journalists, research stated, "Silica nanoparticles (SNPs) are becoming favorable carriers for drug delivery or gene therapy, and in turn, the toxic effect of SNPs on biological systems is gaining attention. Currently, autophagy is recognized as an emerging toxicity mechanism triggered by nanomaterials, yet there have been scarcely research about the mechanisms of autophagy and autophagic cell death associated with SNPs."
The news reporters obtained a quote from the research from the Chinese University of Hong Kong, "In this study, we verified the activation of SNPs-induced autophagy via the MDC-staining and LC3-I/LC3-II conversion, resulted in a dose-dependent manner. The typically morphological characteristics (autophagosomes and autolysosomes) of the autophagy process were observed in TEM ultrastructural analysis. In addition, the autophagic cell death was evaluated by cellular co-staining assay. And the underlying mechanisms of autophagy and autophagic cell death were performed using the intracellular ROS detection, autophagy inhibitor and ROS scavenger. Results showed that the elevated ROS level was in line with the increasing of autophagy activation, while both the 3-MA and NAC inhibitors effectively suppressed the autophagy and cell death induced by SNPs."
According to the news reporters, the research concluded: "In summary, our findings demonstrated that the SNPs-induced autophagy and autophagic cell death were triggered by the ROS generation in HepG2 cells, suggesting that exposure to SNPs could be a potential hazardous factor for maintaining cellular homeostasis."
For more information on this research see: Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species. Journal of Hazardous Materials, 2014;270():176-186. Journal of Hazardous Materials can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Hazardous Materials - www.elsevier.com/wps/product/cws_home/502691)
Our news correspondents report that additional information may be obtained by contacting Y.B. Yu, Chinese University of Hong Kong, Sch Public Hlth & Primary Care, Hong Kong, Hong Kong, People's Republic of China. Additional authors for this research include J.C. Duan, Y. Yu, Y. Li, X.M. Liu, X.Q. Zhou, K.F. Ho, L.W. Tian and Z.W. Sun (see also Nanoparticles).
Keywords for this news article include: Asia, Hong Kong, Chalcogens, Nanotechnology, Oxygen Compounds, Emerging Technologies, Reactive Oxygen Species, People's Republic of China
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