News Column

New Findings from Palacky University in Cancer Therapy Provides New Insights

June 4, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Oncology have been published. According to news reporting out of Olomouc, Czech Republic, by NewsRx editors, research stated, "This study describes a one-pot synthesis of superparamagnetic maghemite-based 4-aminobenzoic acid-coated spherical core-shell nanoparticles (PABA@FeNPs) as suitable nanocomposites potentially usable as magnetic carriers for drug delivery."

Our news journalists obtained a quote from the research from Palacky University, "The PABA@FeNPs system was subsequently functionalized by the activated species (1* and 2*) of highly in vitro cytotoxic cis-[PtCl2(3Claza)(2)] (1; 3Claza stands for 3-chloro-7-azaindole) or cis-[PtCl2(5Braza)(2)] (2; 5Braza stands for 5-bromo-7-azaindole), which were prepared by a silver(I) ion assisted dechlorination of the parent dichlorido complexes. The products 1*@PABA@FeNPs and 2*@PABA@FeNPs, as well as an intermediate PABA@FeNPs, were characterized by a combination of various techniques, such as Mossbauer, FTIR and EDS spectroscopy, thermal analysis, SEM and TEM."

According to the news editors, the research concluded: "The results showed that the products consist of well-dispersed maghemite-based nanoparticles of 13 nm average size that represent an easily obtainable system for delivery of highly cytotoxic cisplatin-like complexes in oncological practice."

For more information on this research see: 4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles. Molecules, 2014;19(2):1622-1634. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)

Our news journalists report that additional information may be obtained by contacting P. Starha, Palacky Univ, Reg Center Adv Technol & Mat, Dept. of Expt Phys, Fac Sci, CZ-77146 Olomouc, Czech Republic. Additional authors for this research include M. Stavarek, J. Tucek and Z. Travnicek (see also Oncology).

Keywords for this news article include: Antineoplastics, Pharmaceuticals, Drugs, Europe, Olomouc, Therapy, Oncology, Cisplatin, Nanoparticle, Czech Republic, Nanotechnology, Carboxylic Acids, Alkylating Agents, Organic Chemicals, Chlorine Compounds, Nitrogen Compounds, Platinum Compounds, 4-Aminobenzoic Acid, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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