News Column

New Findings from Nankai University Update Understanding of Proinsulin

June 3, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Peptide Proteins have been published. According to news reporting originating from Tianjin, People's Republic of China, by NewsRx correspondents, research stated, "To develop a novel nanocarrier with mucoadhesion and enzymatic inhibition for transnasal insulin delivery. Methods & methods: The physicochemical characterization of the nanoparticles included size and morphology, as well as mucoadhesion and enzymatic inhibition."

Our news editors obtained a quote from the research from Nankai University, "The in vitro release of insulin from the nanoparticles was evaluated in 3 mg/ml glucose medium. The cytocompatibility of the nanoparticles was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The interactions of the nanoparticles with Caco-2 cells and nasal epithelia, and the effect of the nanoparticles on transnasal insulin delivery were estimated. The nanoparticles were spherical in shape, with an average size of 100 nm, and presented strong enzymatic inhibitory activity and high mucin adsorption ability. The insulin-loaded nanoparticles showed the rapid insulin release in 3 mg/ml glucose medium. The nanoparticles were noncytotoxic to Caco-2 cells."

According to the news editors, the research concluded: "Furthermore, the insulin-loaded nanoparticles overcame mucosal barriers and significantly decreased plasma glucose levels."

For more information on this research see: Mucoadhesive and enzymatic inhibitory nanoparticles for transnasal insulin delivery. Nanomedicine, 2014;9(4):451-464. Nanomedicine can be contacted at: Future Medicine Ltd, Unitec House, 3RD Floor, 2 Albert Place, Finchley Central, London, N3 1QB, England. (Elsevier -; Nanomedicine -

The news editors report that additional information may be obtained by contacting Y.X. Wang, Nankai Univ, Inst Polymer Chem, Tianjin 300071, People's Republic of China. Additional authors for this research include X.G. Zhang, C. Cheng and C.X. Li (see also Peptide Proteins).

Keywords for this news article include: Asia, Tianjin, Proinsulin, Nanoparticle, Nanotechnology, Peptide Hormones, Peptide Proteins, Emerging Technologies, People's Republic of China

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Source: Life Science Weekly

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