News Column

New Findings from Namik Kemal University in the Area of Peptide Receptors Reported

June 3, 2014



By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Membrane Proteins is now available. According to news originating from Tekirdag, Turkey, by NewsRx correspondents, research stated, "A specific and sensitive biosensor was developed successfully for quantitative detection of human epidermal growth factor receptor by electrochemical impedance spectroscopy. Anti-human epidermal growth factor receptor antibody was covalently immobilized onto a screen-printed carbon electrode modified with a carbon nanotube."

Our news journalists obtained a quote from the research from Namik Kemal University, "Immobilization steps were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). After human epidermal growth factor receptor ligates with anti-human epidermal growth factor receptor immobilized onto an electrode surface, charge transfer resistance changes considerably. This electrochemical response was correlated with human epidermal growth factor receptor concentration. Under optimal conditions, the proposed biosensor could detect human epidermal growth factor receptor 2 fg/mL with a linear range from 2 to 14 fg/mL, showing high sensitivity. Kramers-Kronig Transform was performed on the experimental impedance data. Meanwhile, in a biosensor system, the Single Frequency Impedance technique was first used for characterization of interaction between human epidermal growth factor receptor and anti-human epidermal growth factor receptor."

According to the news editors, the research concluded: "Eventually, the proposed biosensor was applied to artificial serum samples spiked with human epidermal growth factor receptor."

For more information on this research see: A novel impedimetric disposable immunosensor for rapid detection of a potential cancer biomarker. International Journal of Biological Macromolecules, 2014;66():273-280. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)

The news correspondents report that additional information may be obtained from E. Asav, Namik Kemal Univ, Fac Sci, Dept. of Chem, Div Biochem, Tekirdag, Turkey (see also Membrane Proteins).

Keywords for this news article include: Turkey, Cancer, Eurasia, Tekirdag, Oncology, Chemistry, Biosensing, Bioengineering, Electrochemical, Bionanotechnology, Membrane Proteins, Nanobiotechnology, Peptide Receptors, Growth Factor Receptors

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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