By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Macrophages is now available. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "In an attempt to improve implant-bone integration and accelerate bone fracture healing from resisting osteoclastic resorption point of view, we have employed a novel procedure to develop a mesoporous silica nanoparticles/hydroxyapatite (MSNs/HA) composite coating onto stainless Kirschner wire substrate. Characterizations of the surface microstructures indicated enlarged specific surface area compared to HA-coated wires as control, thus the MSNs/HA composite coated implants are endowed with abilities to locally deliver biomedical substances and enhance fracture healing."
Our news journalists obtained a quote from the research from the Chinese Academy of Science, "Herein, zoledronic acid (ZOL) as a model drug, different doses of which were immobilized in the mesoporous coating toward decreasing osteoclastic resorption activity. The loading capacities of ZOL increased almost eight-folds to that of pure HA coating, and the introduction of MSNs obviously retarded ZOL release to achieve a more sustained release profile. After certain periods of osteoclast like cells co-culturing with ZOL contained wires, tartrat-resistant acid phosphatases (TRAP) staining of polynucleated cells and a pit formation assay were performed to investigate the ZOL dose-dependent anti-resorption activity."
According to the news editors, the research concluded: "The promoted local effect on osteoclasts will be of clinical benefit to support implant integration and bone repair."
For more information on this research see: Mesoporous Silica Nanoparticles/Hydroxyapatite Composite Coated Implants to Locally Inhibit Osteoclastic Activity. ACS Applied Materials & Interfaces, 2014;6(8):5456-5466. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting M. Zhu, Chinese Academy Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram, Shanghai 200050, People's Republic of China. Additional authors for this research include Y.F. Zhu, B. Ni, N. Xie, X.H. Lu, J.L. Shi, Y. Zeng and X. Guo (see also Macrophages).
Keywords for this news article include: Asia, Shanghai, Phosphates, Macrophages, Osteoclasts, Nanoparticle, Bone Research, Nanotechnology, Hydroxyapatites, Phosphoric Acids, Emerging Technologies, People's Republic of China
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